Selective reduction of nitrones and nitroxides to functionalized secondary amines

…, T Kálai, NM Bárácz, G Jerkovich, K Hideg

Index: Sar; Kalai; Baracz; Jerkovich; Hideg Synthetic Communications, 1995 , vol. 25, # 19 p. 2929 - 2940

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Citation Number: 38

Abstract

Abstract: Nitrones and nitroxides were selectively reduced with Fe/AcOH to secondary amines in the presence of different functional groups (aldehyde, nitrile, carboxylic ester, activated and nonactivated double or triple bonds). ... The synthetic route through reductive cyclization of y-nitroketones obtained ... Searching for new antiarrhythmic compounds we found that sterically ... These findings forced us to investigate the methods for selective reduction