Peptides. VII. Some sulfonates of strongly acidic N-hydroxy compounds as novel coupling reagents.

M Itoh, H Nojima, J Notani, D Hagiwara…

Index: Itoh,M. et al. Bulletin of the Chemical Society of Japan, 1978 , vol. 51, p. 3320 - 3329

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Citation Number: 17

Abstract

Sulfonates of strongly acidic N-hydroxy compounds such as 6-chloro-1-(p- chlorophenylsulfonyloxy) benzotriazole have been found to be excellent coupling reagents for amide bond formation. Amides can be prepared through either an active ester or a mixed anhydride according to the chosen procedure. Several active esters and protected di-and tripeptides prepared are listed in the Tables. Racemization, possible side reactions, and ...