Cyclocondensation of ethyl nitroacetate with 2-hydroxybenzaldehydes

NA Gavrilova, ES Semichenko, OS Korotchenko…

Index: Gavrilova; Semichenko; Korotchenko; Suboch Russian Journal of Organic Chemistry, 2008 , vol. 44, # 4 p. 624 - 625

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Abstract

Coumarins having a nitrogen-containing substituent in the 3-position are known to exhibit biological activity. For example, 3-nitrocoumarin inhibits phospholipase C in pathogenic yeasts Candida albicans [1]. This compound is prepared by hydrolysis of 3-nitro-2H- chromen-2-imine which is obtained by cyclocondensation of nitroacetonitrile with salicylaldehyde in the presence of methylamine [2]. The synthesis of 3-nitrocoumarin by ...

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