Synthesis and crystal structures of cis-and trans-1-(3′-N, N-dimethylthiocarbamoyl-4′-methoxy)-2-(3 ″, 4 ″, 5 ″trimethoxyphenyl) ethene

DA Ramirez, J Zhang, K Klausmeyer…

Index: Ramirez, Daniel A.; Zhang, Jianxing; Klausmeyer, Kevin; Kane, Robert R. Journal of Chemical Crystallography, 2005 , vol. 35, # 3 p. 227 - 232

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Abstract

Abstract The combretastatin A-4 analogue cis-1-(3′-N, N-dimethylthiocarbamoyl-4′- methoxy)-2-(3 ″, 4 ″, 5 ″-trimethoxyphenyl) ethene (1) and its trans stereoisomer (2) were synthesized. The molecular structures of these compounds were obtained by single-crystal X-ray diffraction. Crystallization of 1 occurs in the centrosymmetric monoclinic space group C 2/c (No. 15) with a= 21.468 (5), b= 7.932 (1), c= 23.949 (3); and β= 100.75 (1)∘ and Z= 8. ...

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