The Role of New Technologies in Defining a Manufacturing Process for PPARα Agonist LY518674†

…, JW Fennell, MA LaPack, RR Rothhaar…

Index: Argentine, Mark D.; Braden, Timothy M.; Czarnik, Jeffrey; Conder, Edward W.; Dunlap, Steven E.; Fennell, Jared W.; LaPack, Mark A.; Rothhaar, Roger R.; Scherer, R. Brian; Schmid, Christopher R.; Vicenzi, Jeffrey T.; Wei, Jeffrey G.; Werner, John A.; Roginski, Robert T. Organic Process Research and Development, 2009 , vol. 13, # 2 p. 131 - 143

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Citation Number: 14

Abstract

The impact of several new technologies on the development of a manufacturing process for LY518674 is described. Extensive use of process analytical technology (PAT) throughout development, both at laboratory and pilot-plant scale, enabled data-rich experiments, shortened development cycle times, and obviated the requirement of PAT for process control at larger scale. In situ ReactIR was used to develop a kinetic model for a one-pot ...

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