LY518674
Modify Date: 2026-07-01 11:42:24
LY518674 structure
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Common Name | LY518674 | ||
|---|---|---|---|---|
| CAS Number | 425671-29-0 | Molecular Weight | 409.47800 | |
| Density | 1.21g/cm3 | Boiling Point | 575.852ºC at 760 mmHg | |
| Molecular Formula | C23H27N3O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 302.065ºC | |
Use of LY518674LY518674 is a potent, selective PPARα antagonist, with an EC50 of 42 nM for human PPARα. LY518674 reduces triglycerides in and increased HDL-C and is used for the treatment of atherosclerosis[1][2][3]. |
| Name | 2-[4-[3-[2,5-dihydro-1-[(4-methylphenyl)methyl]-5-oxo-1H-1,2,4-triazol-3-yl]propyl]phenoxy]-2-methylpropanoic acid |
|---|---|
| Synonym | More Synonyms |
| Description | LY518674 is a potent, selective PPARα antagonist, with an EC50 of 42 nM for human PPARα. LY518674 reduces triglycerides in and increased HDL-C and is used for the treatment of atherosclerosis[1][2][3]. |
|---|---|
| Related Catalog | |
| Target |
EC50: 42 nM (human PPARα)[1] |
| In Vivo | LY518674 reduces triglycerides and increased HDL-C in vivo[2]. LY518674 substantially increases apolipoprotein A-I (apoA-I) turnover without major impact on steady-state levels of apoA-I or high-density lipoprotein-cholesterol (HDL-C) [3]. |
| References |
| Density | 1.21g/cm3 |
|---|---|
| Boiling Point | 575.852ºC at 760 mmHg |
| Molecular Formula | C23H27N3O4 |
| Molecular Weight | 409.47800 |
| Flash Point | 302.065ºC |
| Exact Mass | 409.20000 |
| PSA | 97.21000 |
| LogP | 3.34540 |
| Index of Refraction | 1.594 |
| Storage condition | 2-8°C |
![tert-butyl 2-[4-(4-hydrazinyl-4-oxobutyl)phenoxy]-2-methylpropanoate Structure](https://image.chemsrc.com/caspic/142/425672-62-4.png)
CAS#:425672-62-4
CAS#:20637-08-5
CAS#:22320-10-1![4-[4-(1-tert-butoxycarbonyl-1-methylethoxy)phenyl]butyric acid methyl ester Structure](https://image.chemsrc.com/caspic/180/425672-61-3.png)
CAS#:425672-61-3![2-(4-{3-[4-(2,4-dimethoxybenzyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]propyl}phenoxy)-2-methylpropionic acid Structure](https://image.chemsrc.com/caspic/439/425669-64-3.png)
CAS#:425669-64-3|
Name: Cotransfection activity against human Peroxisome proliferator activated receptor alph...
Source: ChEMBL
Target: Peroxisome proliferator-activated receptor alpha
External Id: CHEMBL760605
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Name: Compound was evaluated in human apoA-I transgenic mice for maximal percent increase i...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL721333
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Name: Compound was evaluated in human apoA-I transgenic mice for its ability to alter serum...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL722168
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Name: Compound was evaluated in human apoA-I transgenic mice for its ability to alter HDL-c...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL722167
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Name: Human Peroxisome proliferator-activated receptor-alpha (1C. Peroxisome proliferator-a...
Source: IUPHAR-DB
Target: Peroxisome proliferator-activated receptor-alpha (1C. Peroxisome proliferator-activated receptors) [Homo sapiens]
External Id: 593_Human
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Name: Agonist activity at PPARalpha
Source: ChEMBL
Target: Peroxisome proliferator-activated receptor alpha
External Id: CHEMBL2038446
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Name: Agonist activity at PPARdelta
Source: ChEMBL
Target: Peroxisome proliferator-activated receptor delta
External Id: CHEMBL2038596
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Name: Agonist activity at PPARgamma
Source: ChEMBL
Target: Peroxisome proliferator-activated receptor gamma
External Id: CHEMBL2038597
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Total 8, Current Page 1 of 1
1
| 2-Methyl-2-[4-[3-[1-(4-Methylbenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl]propyl]phenoxy]propionic acid |
| Propanoic acid,2-[4-[3-[2,5-dihydro-1-[(4-methylphenyl)methyl]-5-oxo-1H-1,2,4-triazol-3-yl]propyl]phenoxy]-2-methyl |
| 2-[4-[3-[4,5-dihydro-1-[(4-methylphenyl)methyl]-5-oxo-1H-1,2,4-triazol-3-yl]propyl]phenoxy]-2-methylpropanoic acid |
| 2-[4-[3-[2,5-dihydro-1-[(4-methylphenyl)methyl]-5-oxo-1H-1,2,4-triazol-3-yl]propyl]phenoxy]-2-methyl-propanoic acid |