Helvetica Chimica Acta

Nucleotide. XIV. Substituierte β??Phenyläthyl??Gruppen. Neue Schutzgruppen für Oligonucleotid??Synthesen nach dem Phosphorsäuretriester??Verfahren

E Uhlmann, W Pfleiderer

Index: Uhlmann, Eugen; Pfleiderer, Wolfgang Helvetica Chimica Acta, 1981 , vol. 64, # 5 p. 1688 - 1703

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Citation Number: 52

Abstract

Summary Various 0-and p-substituted 8-phenylethanols (2-10) have been synthesized and investigated as blocking groups in the phosphotriester approach. A large number of 5'Otritylated thymidine-3'-phosphotriesters (13-36) with two different phosphate protecting groups have been prepared, characterized, and studied according to their chemical stability and usefullness for oligonucleotide syntheses. The combination of a 5'-O- ...

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