Synthesis of 8-oxo-7, 8-dihydro-6-O-methyl-2′-deoxyguanosine and its use as a probe to study DNA-base excision by MutY enzyme

CV Varaprasad, N Bulychev, AP Grollman, F Johnson

Index: Varaprasad, Chamakura V.; Bulychev, Nickolai; Grollman, Arthur P.; Johnson, Francis Tetrahedron Letters, 1996 , vol. 37, # 1 p. 9 - 12

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Citation Number: 10

Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A 23mer oligomer containing 8-oxo-7,8-dihydro-6-O-methyl-2′-deoxyguanosine (1) has been synthesized from 2′-deoxyguanosine. The activity of MutY protein toward this and a related oligomer containing 8-methoxy-dG has been studied. ... A 23mer oligomer containing ...