Enzymatic resolution of alicyclic 1, 3-amino alcohols in organic media

M Péter, J Van der Eycken, G Bernáth, F Fülöp

Index: Peter, Maria; Van Der Eycken, Johan; Bernath, Gabor; Fueloep, Ferenc Tetrahedron Asymmetry, 1998 , vol. 9, # 13 p. 2339 - 2347

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Citation Number: 16

Abstract

Racemic cis-and trans-2-aminocyclohexane-1-methanol and cis-and trans-2-amino-4- cyclohexene-1-methanol were resolved via lipase-catalysed O-acylation of their Z derivatives, using vinyl butyrate in different ether solvents. In accordance with the empirical rule, most of the screened lipases preferred the 1S enantiomer.