Chemistry of 4-fluoroglutamic acid. Part 2. Separation of the diastereomers on a large scale. Preparation of cis-and trans-4-fluoro-5-pyrrolidone-2-carboxylic acids (4- …

V Tolman, V Vlasakova, J Němeček

Index: Tolman, V.; Vlasakova, V.; Nemecek, J. Journal of Fluorine Chemistry, 1993 , vol. 60, # 2.3 p. 185 - 191

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Citation Number: 8

Abstract

Abstract Separation of the 4-fluoroglutamic acid diastereomers has been achieved by crystallizationof the hydrochlorides of their dialkyl esters 1b and 2d. Subsequent hydrolysis affordedthe diastereomers 1a and 2a in 100% steric purity. Conversion of the acids into the