New 3-methylquinoxaline-2-carboxamide 1, 4-di-N-oxide derivatives as anti-Mycobacterium tuberculosis agents

…, A Burguete, E Torres, S Pérez-Silanes, I Aldana…

Index: Ancizu, Saioa; Moreno, Elsa; Solano, Beatriz; Villar, Raquel; Burguete, Asuncion; Torres, Enrique; Perez-Silanes, Silvia; Aldana, Ignacio; Monge, Antonio Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 7 p. 2713 - 2719

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Citation Number: 51

Abstract

Mycobacterium tuberculosis (M. Tb) is a bacillus capable of causing a chronic and fatal condition in humans known as tuberculosis (TB). It is estimated that there are 8 million new cases of TB per year and 3.1 million infected people die annually. Thirty-six new amide quinoxaline 1, 4-di-N-oxide derivatives have been synthesized and evaluated as potential anti-tubercular agents, obtaining biological values similar to the reference compound, ...