Synthesis of 5-chloro-5, 8-dideaza analogs of folic acid and aminopterin targeted for colon adenocarcinoma

…, A Kumar, A Tomazic, WL Washtien

Index: Hynes; Kumar; Tomazic; Washtien Journal of Medicinal Chemistry, 1987 , vol. 30, # 8 p. 1515 - 1519

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Citation Number: 13

Abstract

2b quisite 6-aminoquinazoline with diethyl p-formylbenzoyl-L-glutamate were unsuccessful, yielding extremely complex reaction mixtures. While this approach was successful in the case of 6-aminoquinazolines possessing either hydrogen or methyl at position 5, 5J0 the presence of the electron-withdrawing chlorine atom at position 5 apparently renders the 6- amino function insufficiently nucleophilic to effect clean reductive condensation in the ...