ZnCl2??Mediated Synthesis of Carboxylic Anhydrides using 2??Acyl??4, 5??dichloropyridazin??3 (2 H)??ones

YD Park, JJ Kim, HK Kim, SD Cho, YJ Kang…

Index: Park, Yong-Dae; Kim, Jeum-Jong; Kim, Ho-Kyun; Cho, Su-Dong; Kang, Young-Jin; Park, Ki Hun; Lee, Sang-Gyeong; Yoon, Yong-Jin Synthetic Communications, 2005 , vol. 35, # 3 p. 371 - 378

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Citation Number: 13

Abstract

Abstract ZnCl2 is an efficient catalyst for synthesis of carboxylic acid anhydride from 2??acyl?? 4, 5??dichloropyridazin??3 (2 H)??ones. Treatment of 2??acyl??4, 5??dichloropyridazin??3 (2 H)?? ones with ZnCl2 (0.5 equivalents) and air in refluxing dry THF or acetonitrile gave the corresponding symmetric acid anhydrides in good to excellent yield.

Phase managed organic synthesis 2. A new polymer assisted synthesis of acid anhydrides.

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