Rabbit 3-hydroxyhexobarbital dehydrogenase is a NADPH-preferring reductase with broad substrate specificity for ketosteroids, prostaglandin D 2, and other …

…, O El-Kabbani, K Tajima, Y Bunai, S Yamano…

Index: Endo, Satoshi; Matsunaga, Toshiyuki; Matsumoto, Atsuko; Arai, Yuki; Ohno, Satoshi; El-Kabbani, Ossama; Tajima, Kazuo; Bunai, Yasuo; Yamano, Shigeru; Hara, Akira; Kitade, Yukio Biochemical Pharmacology, 2013 , vol. 86, # 9 p. 1366 - 1375

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Abstract

Abstract 3-Hydroxyhexobarbital dehydrogenase (3HBD) catalyzes NAD (P)+-linked oxidation of 3-hydroxyhexobarbital into 3-oxohexobarbital. The enzyme has been thought to act as a dehydrogenase for xenobiotic alcohols and some hydroxysteroids, but its physiological function remains unknown. We have purified rabbit 3HBD, isolated its cDNA, and examined its specificity for coenzymes and substrates, reaction directionality and ...

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