Microwave-assisted synthesis of substituted fluoroazines using KF· 2H 2 O

AM Shestopalov, AE Fedorov, LA Rodinovskaya…

Index: Shestopalov, Anatoliy M.; Fedorov, Alexander E.; Rodinovskaya, Liudmila A.; Shestopalov, Alexander A.; Gakh, Andrei A. Tetrahedron Letters, 2009 , vol. 50, # 37 p. 5257 - 5259

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Citation Number: 8

Abstract

This Letter describes a new microwave-assisted fluorination of azines using hydrated potassium fluoride in untreated DMSO under atmospheric conditions. It is thought that microwave irradiation promotes desolvation of the fluorine anion leading to halide nucleophilic substitution.