N-(Methanesulfonyl)-16-phenoxyprostaglandin carboxamides: tissue-selective, uterine stimulants
…, JS Bindra, JF Eggler, JJ Plattner…
Index: Schaaf, Thomas K.; Bindra, Jasjit S.; Eggler, James F.; Plattner, Jacob J.; Nelson, A. James; et al. Journal of Medicinal Chemistry, 1981 , vol. 24, # 11 p. 1353 - 1359
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Citation Number: 31
Abstract
In an effort to develop tissue-selective prostaglandin analogues resistant to the metabolic inactivating pathways of the natural materials, hybrid compounds modified both at C-1 with a sdfonimide moiety and in the n-amylcarbinol side chain with substituted phenoxy group were synthesized and evaluated in a variety of in vitro and in vivo models. Several of theae analogues exhibited potent, tissueselective, uterine stimulant activity, a fmding ...
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[DeLong, Mitchell A.; Amburgey, Jack; Taylor, Cynthia; Wos, John A.; Soper, David L.; Wang, Yili; Hicks, Renee Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 14 p. 1519 - 1522]
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