Journal of the American Chemical Society

Nitrogen Analogs of Ketenes. V. 1 Formation of the Peptide Bond

CL Stevens, ME Munk

Index: Stevens; Munk Journal of the American Chemical Society, 1958 , vol. 80, p. 4069

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Citation Number: 9

Abstract

Xitrogen analogs of ketenes have been used as reagents for the formation of the peptide bond. The N-protected amino acids glycine, alanine and methionine were converted in high yield to stable, crystalline adducts with the ketenimine I. The adducts were formed in non- polar, aqueous or alcoholic solutions. Reaction of an amino acid ester with an adduct afforded the peptides; alternately, the three starting materials could be placed in the ...