Organic Letters 2000-11-30

Synthesis of 6-acetamido-5-amino- and -5-guanidino-3, 4-dehydro-N-(2-ethylbutyryl)- 3-piperidinecarboxylic acids related to zanamivir and oseltamivir, inhibitors of influenza virus neuraminidases.

E Shitara, Y Nishimura, K Nerome, Y Hiramoto, T Takeuchi

Index: Org. Lett. 2(24) , 3837-40, (2000)

Full Text: HTML

Abstract

[reaction: see text] 6-Acetamido-5-amino- and -5-guanidino-3, 4-dehydro-N-(2-ethylbutyryl)-3-piperidinecarboxylic acids (8 and 9) have been synthesized starting from natural siastatin B, a bacterial neuraminidase inhibitor isolated from Streptomyces culture in a stereospecific fashion. These compounds are related to zanamivir and oseltamivir, inhibitors of influenza virus neuraminidases.

Related Compounds

  • Siastatin B micro...

Related Articles:

Contributions of NanI sialidase to Caco-2 cell adherence by Clostridium perfringens type A and C strains causing human intestinal disease.

2014-11-01

[Infect. Immun. 82(11) , 4620-30, (2014)]

Syntheses and activities of N-substituted derivatives of siastatin B.

1992-10-01

[J. Antibiot. 45(10) , 1662-8, (1992)]

Synthesis of 3-episiastatin B analogues having anti-influenza virus activity.

1993-12-01

[J. Antibiot. 46(12) , 1883-9, (1993)]

Synthesis of the sialidase inhibitor siastatin B.

2007-05-01

[Org. Lett. 2 , 4037, (2000)]

A-72363 A-1, A-2, and C, novel heparanase inhibitors from Streptomyces nobilis SANK 60192, II. Biological activities.

1996-01-01

[J. Antibiot. 49(1) , 61-4, (1996)]

More Articles...