Siastatin B microbial
Siastatin B microbial structure
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Common Name | Siastatin B microbial | ||
|---|---|---|---|---|
| CAS Number | 54795-58-3 | Molecular Weight | 218.20700 | |
| Density | 1.48g/cm3 | Boiling Point | 579.2ºC at 760 mmHg | |
| Molecular Formula | C8H14N2O5 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 304.1ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Contributions of NanI sialidase to Caco-2 cell adherence by Clostridium perfringens type A and C strains causing human intestinal disease.
Infect. Immun. 82(11) , 4620-30, (2014) Previous studies showed that Clostridium perfringens type D animal disease strain CN3718 uses NanI sialidase for adhering to enterocyte-like Caco-2 cells. The current study analyzed whether NanI is similarly important when type A and C human intestinal diseas... |
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Syntheses and activities of N-substituted derivatives of siastatin B.
J. Antibiot. 45(10) , 1662-8, (1992) N-Substituted derivatives of siastatin B have been obtained by a chemical modification. Some derivatives showed potent inhibitory activities against Streptococcus sp. and Clostridium perfringens neuraminidases. |
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Synthesis of 3-episiastatin B analogues having anti-influenza virus activity.
J. Antibiot. 46(12) , 1883-9, (1993) Two epimers of siastatin B, 3-episiastatin B (3) and 3,4-diepisiastatin B (4), were obtained by the chemical modification of siastatin B. Compound 3 showed marked inhibitory activity against influenza virus neuraminidases and significant inhibition of influen... |
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Synthesis of the sialidase inhibitor siastatin B.
Org. Lett. 2 , 4037, (2000) [structure] The resolved piperidinecarboxylate (R)-7 was converted to siastatin B (1) by an efficient and stereoselective sequence that includes a bromo-beta-lactonization and an N-acyliminium azidation. Two analogues (3 and 4) of siastatin were also prepared... |
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A-72363 A-1, A-2, and C, novel heparanase inhibitors from Streptomyces nobilis SANK 60192, II. Biological activities.
J. Antibiot. 49(1) , 61-4, (1996) Inhibitory activities of A-72363 A-1, A-2 and C, the diastereomers of a neuraminidase inhibitor siastatin B, against various glycosidases were tested in comparison to siastatin B. Despite these compounds differing only in their configuration, each compound sh... |
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A-72363 A-1, A-2 and C, novel heparanase inhibitors from Streptomyces nobilis SANK 60192. I. Taxonomy of producing organism, fermentation, isolation and structure elucidation.
J. Antibiot. 49(1) , 54-60, (1996) Novel heparanse inhibitors, A72363 A-1, A-2, and C, were isolated from the culture filtrate of Streptomyces nobilis SANK 60192 by column chromatography on various resinous adsorbents, followed by preparative anion exchange HPLC. Spectroscopic studies revealed... |
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Synthesis and antimetastatic activity of L-iduronic acid-type 1-N-iminosugars.
J. Med. Chem. 40(16) , 2626-33, (1997) L-Iduronic acid-type 1-N-iminosugars, (3R,4S,5R,6R)- and (3R,4S,5S,6R)-6-acetamido-4-amino-5-hydroxypiperidine-3-carboxylic acid (6 and 7, respectively), (3R,4S,5R,6R)-6-acetamido-4- guanidino-5-hydroxypiperidine-3-carboxylic acid (8), and (3R,4S,5R,6R)-4-ami... |
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Synthesis and activity of 1-N-iminosugar inhibitors, siastatin B analogues for alpha-N-acetylgalactosaminidase and beta-N-acetylglucosaminidase.
Bioorg. Med. Chem. 4(1) , 91-6, (1996) N-Acetylgalactosamine-based 1-N-iminosugars, new types of glycosidase inhibitor have been synthesized by modeling on siastatin B, isolated from a Streptomyces culture. The analogues of siastatin B were proved to be potent inhibitors for alpha-N-acetylgalactos... |
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A facile synthesis of D-glucose-type gem-diamine 1-N-iminosugars: a new family of glucosidase inhibitors.
Bioorg. Med. Chem. 7(6) , 1241-6, (1999) gem-Diamine 1-N iminosugars of D-glucose-type, a new type of glycosidase inhibitors, have been synthesized from siastatin B, isolated from Streptomyces culture. 2-Trifluoroacetamido-1-N-iminosugar, (2S,3R,4R,5R)-2-trifluoroacetamido-5-hydroxymethylpiperidine ... |
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Synthesis of 6-acetamido-5-amino- and -5-guanidino-3, 4-dehydro-N-(2-ethylbutyryl)- 3-piperidinecarboxylic acids related to zanamivir and oseltamivir, inhibitors of influenza virus neuraminidases.
Org. Lett. 2(24) , 3837-40, (2000) [reaction: see text] 6-Acetamido-5-amino- and -5-guanidino-3, 4-dehydro-N-(2-ethylbutyryl)-3-piperidinecarboxylic acids (8 and 9) have been synthesized starting from natural siastatin B, a bacterial neuraminidase inhibitor isolated from Streptomyces culture i... |