European Journal of Medicinal Chemistry 2000-09-01

Synthesis of ionones and carvone analogues: olfactory properties and preliminary toxicity assays.

M Anzaldi, E Sottofattori, F Dusatti, M Ferro, M Pani, A Balbi

Index: Eur. J. Med. Chem. 35(9) , 797-803, (2000)

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Abstract

Vilsmeier reagents react with alpha/beta-ionones and carvone to produce aldehydes 7-11 in a one-step procedure. The indene derivative 11, which came from the double iminoalkylation of carvone and ring closure with the elimination of dimethylamine, was practically odourless, while all the others had peculiar odours which were very different from the starting material. The cytotoxicity data of 9 and 10, which are the most promising potential perfume ingredients, are also reported.

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