Extension of the Heck reaction to the arylation of activated thiophenes

L Lavenot, C Gozzi, K Ilg, I Orlova, V Penalva…

Index: Lavenot; Gozzi; Ilg; Orlova; Penalva; Lemaire Journal of Organometallic Chemistry, 1998 , vol. 567, # 1-2 p. 49 - 55

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Citation Number: 100

Abstract

The direct arylation of activated thiophenes was accomplished in moderate to good yields using a Heck-type reaction with the mixture of Pd (OAc) 2 and n-Bu4NBr as a catalytic system. This new arylation method is applied to different derivatives and has proved to be compatible with sensitive functional groups. Furthermore, the substituent nature and position on the thiophene moiety influence the cross coupling. In particular the substitution is ...

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