Bioorganic & Medicinal Chemistry Letters 2012-01-01

Novel 2-(2-(4-aryloxybenzylidene) hydrazinyl)benzothiazole derivatives as anti-tubercular agents.

Vikas N Telvekar, Vinod Kumar Bairwa, Kalpana Satardekar, Anirudh Bellubi

Index: Bioorg. Med. Chem. Lett. 22 , 649-52, (2012)

Full Text: HTML

Abstract

A series of structurally novel, substituted 2-(2-(4-aryloxybenzylidene) hydrazinyl)benzothiazole derivatives incorporating 2-hydrazinyl benzothiazole and 4-(aryloxy)benzaldehyde were designed and synthesized using molecular hybridization approach. All the synthesized compounds exhibited promising activity (MIC 1.5-29.00μg/ml) against Mycobacteriumtuberculosis H37Rv strains of using REMA. Five of the evaluated compounds exhibit MIC <3.0μg/ml. Compound (E)-6-chloro-2-(2-(4-(2,4-dichlorophenoxy)benzylidene)hydrazinyl) benzothiazole showed MIC of 1.5μg/ml. Thus, this compound could act as a potential lead for further development of new anti-tubercular drugs.Copyright © 2011 Elsevier Ltd. All rights reserved.

Related Compounds

  • Isoniazid
  • 4-Phenoxybenzaldeh...
  • Triclosan

Related Articles:

Differential expression of efflux pump genes of Mycobacterium tuberculosis in response to varied subinhibitory concentrations of antituberculosis agents.

2015-03-01

[Tuberculosis (Edinb.) 95(2) , 155-61, (2015)]

Enhancement of in vitro activity of tuberculosis drugs by addition of thioridazine is not reflected by improved in vivo therapeutic efficacy.

2014-12-01

[Tuberculosis (Edinb.) 94(6) , 701-7, (2015)]

Disruption of an M. tuberculosis membrane protein causes a magnesium-dependent cell division defect and failure to persist in mice.

2015-02-01

[PLoS Pathog. 11(2) , e1004645, (2015)]

In vitro and in vivo activities of the nitroimidazole TBA-354 against Mycobacterium tuberculosis.

2015-01-01

[Antimicrob. Agents Chemother. 59(1) , 136-44, (2014)]

Antagonistic effects of indoloquinazoline alkaloids on antimycobacterial activity of evocarpine.

2015-04-01

[J. Appl. Microbiol. 118(4) , 864-72, (2015)]

More Articles...