Isoniazid
Isoniazid structure
|
Common Name | Isoniazid | ||
|---|---|---|---|---|
| CAS Number | 54-85-3 | Molecular Weight | 137.139 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C6H7N3O | Melting Point | 171-173 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | >250°C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
|
Differential expression of efflux pump genes of Mycobacterium tuberculosis in response to varied subinhibitory concentrations of antituberculosis agents.
Tuberculosis (Edinb.) 95(2) , 155-61, (2015) Several reports have elaborated on the role of efflux pumps in drug resistance in Mycobacterium tuberculosis by analysing the mRNA expression profiles. However, there is no uniformity in the subinhibitory concentrations of drugs chosen in these studies. Some ... |
|
|
Enhancement of in vitro activity of tuberculosis drugs by addition of thioridazine is not reflected by improved in vivo therapeutic efficacy.
Tuberculosis (Edinb.) 94(6) , 701-7, (2015) Assessment of the activity of thioridazine towards Mycobacterium tuberculosis (Mtb), in vitro and in vivo as a single drug and in combination with tuberculosis (TB) drugs.The in vitro activity of thioridazine as single drug or in combination with TB drugs was... |
|
|
Disruption of an M. tuberculosis membrane protein causes a magnesium-dependent cell division defect and failure to persist in mice.
PLoS Pathog. 11(2) , e1004645, (2015) The identification of Mycobacterium tuberculosis genes necessary for persistence in vivo provides insight into bacterial biology as well as host defense strategies. We show that disruption of M. tuberculosis membrane protein PerM (Rv0955) resulted in an IFN-γ... |
|
|
In vitro and in vivo activities of the nitroimidazole TBA-354 against Mycobacterium tuberculosis.
Antimicrob. Agents Chemother. 59(1) , 136-44, (2014) Nitroimidazoles are a promising new class of antitubercular agents. The nitroimidazo-oxazole delamanid (OPC-67683, Deltyba) is in phase III trials for the treatment of multidrug-resistant tuberculosis, while the nitroimidazo-oxazine PA-824 is entering phase I... |
|
|
Antagonistic effects of indoloquinazoline alkaloids on antimycobacterial activity of evocarpine.
J. Appl. Microbiol. 118(4) , 864-72, (2015) The interaction of quinolone and indoloquinazoline alkaloids concerning their antimycobacterial activity was studied.The antimycobacterial and modulating activity of evodiamine (1), rutaecarpine (2) and evocarpine (3) was tested on mycobacteria including thre... |
|
|
The efflux pump inhibitor timcodar improves the potency of antimycobacterial agents.
Antimicrob. Agents Chemother. 59(3) , 1534-41, (2015) Previous studies indicated that inhibition of efflux pumps augments tuberculosis therapy. In this study, we used timcodar (formerly VX-853) to determine if this efflux pump inhibitor could increase the potency of antituberculosis (anti-TB) drugs against Mycob... |
|
|
Isoniazid-gelatin conjugate microparticles containing rifampicin for the treatment of tuberculosis.
J. Pharm. Pharmacol. 65(9) , 1302-11, (2013) In this work, a new polymeric microparticle system based on gelatin covalently bound to isoniazid (ISN) and containing rifampicin (RFP) was prepared by spray-drying technique. Microparticle aptitude to nebulisation and their capability of interacting with A54... |
|
|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this st... |
|
|
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
J. Sci. Ind. Res. 65(10) , 808, (2006) Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be tra... |
|
|
The Japanese toxicogenomics project: application of toxicogenomics.
Mol. Nutr. Food. Res. 54 , 218-27, (2010) Biotechnology advances have provided novel methods for the risk assessment of chemicals. The application of microarray technologies to toxicology, known as toxicogenomics, is becoming an accepted approach for identifying chemicals with potential safety proble... |