Synthesis and antiviral activity of new unsaturated pyrimidine acyclonucleosides

AA Ozerov, MS Novikov, AK Brel', OT Andreeva…

Index: Ozerov, A. A.; Novikov, M. S.; Brel', A. K.; Andreeva, O. T.; Vladykov, G. V.; et al. Pharmaceutical Chemistry Journal, 1991 , vol. 25, # 8 p. 560 - 565 Khimiko-Farmatsevticheskii Zhurnal, 1991 , vol. 25, # 8 p. 44 - 47

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Citation Number: 13

Abstract

The investigation of the mechanism of antiviral action showed a general trend for (Ia-c): the compounds are activated in cells infected with herpes virus by the phosphorylation with viral thymidine kinase, and inhibit viral DNA-polymerase in the presence of triphosphates [8, 19, 22]. An analogous mechanism of antiviral action is found for the pyrimidine nucleosides 5-E- (2-bromovinyl)-2'-desoxyuridine [BVDU,(II)][5, 6] and l-(2'-fluoro-2'-desoxy-~-D- ...

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