Praxis 2001-08-16

[Clinical effectiveness and tolerance of climbazole containing dandruff shampoo in patients with seborrheic scalp eczema].

W Wigger-Alberti, K Kluge, P Elsner

Index: Praxis (Bern 1994) 90(33) , 1346-9, (2001)

Full Text: HTML

Abstract

Pityrosporum ovale appears to play an important role in the pathogenesis of dandruff as a symptom of seborrheic dermatitis. Climbazole is an antimycotic agent with a high in vitro and in vivo efficacy against P. ovale. In the presented work we investigated the efficacy and safety of a climbazole 0.65% shampoo on seborrheic dermatitis of 30 volunteers. Subjects were diagnosed as having moderate to severe seborrheic dermatitis of the scalp. After a 1-week washout and a 4-week treatment the clinical evaluation showed a successful reduction of dandruff, skin redness and itching in 80% of the volunteers and a mild improvement in 20% of the volunteers. The cosmetic acceptability was very good by the majority. It is concluded that the formulation tested is effective in the treatment of moderate to severe dandruff.

Related Compounds

  • Climbazole

Related Articles:

Enhanced efficacy and sensory properties of an anti-dandruff shampoo containing zinc pyrithione and climbazole.

2013-02-01

[Int. J. Cosmet. Sci. 35(1) , 78-83, (2013)]

Efficacy of a piroctone olamine/climbazol shampoo in comparison with a zinc pyrithione shampoo in subjects with moderate to severe dandruff.

2011-06-01

[Int. J. Cosmet. Sci. 33(3) , 276-82, (2011)]

[Determination of antidangdruff agent salicylic acid, zinc pyrithione, octopirox, climbazole and ketoconazole in shampoo by high performance liquid chromatography].

2005-09-01

[Wei Sheng Yan Jiu 34(5) , 626-8, (2005)]

Climbazole is a new potent inducer of rat hepatic cytochrome P450.

2001-08-01

[J. Toxicol. Sci. 26(3) , 141-50, (2001)]

[Comparison of the thermostability of natural (sulfoprolamine and sodium usnate) and synthetic (climbazole and piroctone olamine) antidandruff agents].

1999-09-01

[Ann. Pharm. Fr. 57(5) , 392-6, (1999)]

More Articles...