Climbazole
Climbazole structure
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Common Name | Climbazole | ||
|---|---|---|---|---|
| CAS Number | 38083-17-9 | Molecular Weight | 292.761 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 447.5±40.0 °C at 760 mmHg | |
| Molecular Formula | C15H17ClN2O2 | Melting Point | 96-100°C | |
| MSDS | Chinese USA | Flash Point | 224.4±27.3 °C | |
| Symbol |
GHS07, GHS09 |
Signal Word | Warning | |
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Enhanced efficacy and sensory properties of an anti-dandruff shampoo containing zinc pyrithione and climbazole.
Int. J. Cosmet. Sci. 35(1) , 78-83, (2013) Dandruff is a common complaint and is suffered by as much as half of the population at some time post puberty. The condition is characterized by the presence of flakes on the scalp and in the hair, and is often accompanied by itch. The most common treatment f... |
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Efficacy of a piroctone olamine/climbazol shampoo in comparison with a zinc pyrithione shampoo in subjects with moderate to severe dandruff.
Int. J. Cosmet. Sci. 33(3) , 276-82, (2011) Dandruff is a chronic scalp disorder characterized by scaling and itching. A successful anti-dandruff shampoo not only has to provide superior anti-dandruff relief to ensure patient compliance. It also needs to offer excellent cosmetic and hair conditioning b... |
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[Determination of antidangdruff agent salicylic acid, zinc pyrithione, octopirox, climbazole and ketoconazole in shampoo by high performance liquid chromatography].
Wei Sheng Yan Jiu 34(5) , 626-8, (2005) A high performance liquid chromatography method was established for determination of antidangdruff agent salicylic acid,zinc pyrithione, octopirox, climbazole and ketoconazole in shampoo on a C18 column using acetonitrile-metholaqueous solution (10 mmol/L KH2... |
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Climbazole is a new potent inducer of rat hepatic cytochrome P450.
J. Toxicol. Sci. 26(3) , 141-50, (2001) We examined the effect of climbazole on the induction of rat hepatic microsomal cytochrome P450 (P450), and compared the induction potency with other N-substituted azole drugs such as clorimazole. We found that climbazole is found to be a potent inducer of ra... |
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[Clinical effectiveness and tolerance of climbazole containing dandruff shampoo in patients with seborrheic scalp eczema].
Praxis (Bern 1994) 90(33) , 1346-9, (2001) Pityrosporum ovale appears to play an important role in the pathogenesis of dandruff as a symptom of seborrheic dermatitis. Climbazole is an antimycotic agent with a high in vitro and in vivo efficacy against P. ovale. In the presented work we investigated th... |
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[Comparison of the thermostability of natural (sulfoprolamine and sodium usnate) and synthetic (climbazole and piroctone olamine) antidandruff agents].
Ann. Pharm. Fr. 57(5) , 392-6, (1999) We compared thermostability of various natural (sulfoprolamine and sodium usnate) or synthetic (climbazol and piroctone olamine) antidandruff agents in aqueous diluted solution at pH around 7. Thermodegradation of these solutions was studied by an isothermal ... |
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Evaluation of the genotoxicity of the imidazole antifungal climbazole: comparison to published results for other azole compounds.
Mutat. Res. 672(1) , 27-39, (2009) Climbazole is an imidazole antifungal agent that can provide anti-dandruff benefits when incorporated into a shampoo matrix. A series of genotoxicity studies were performed to support the human safety of this azole antifungal drug. Climbazole was not mutageni... |
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In vitro activity of climbazole, clotrimazole and silver-sulphadiazine against isolates of Malassezia pachydermatis.
Zentralbl. Veterinarmed. B 44(4) , 193-7, (1997) Malassezia pachydermatis is a yeast-like, mainly zoophilic fungus, also known as Malassezia canis. It can be isolated in 20-50% from normal ear cerumen specimen from dogs or cats and has an even higher prevalence in non-suppurative otitis externa in animal sp... |
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Induction and inhibition of cytochrome P450 and drug-metabolizing enzymes by climbazole.
Biol. Pharm. Bull. 25(1) , 53-7, (2002) To determine the effect of climbazole on hepatic microsomal cytochrome P450 (P450) and drug-metabolizing enzymes, four different P450 isoforms (CYP2B1, 3A2, 2E1, and 2C12) were examined in female Long-Evans rats. Treatment of rats with climbazole resulted in ... |