Steroids 2010-12-01

The synthesis of androstane brassinosteroid analogues with alpha-azido acid ester groups in position 17beta.

Jaroslava Hnilickova, Ladislav Kohout, Enric Capdevila, Ana Esteve, Marc Vilaplana, Meritxell Molist, Carme Brosa, Jana Swaczynova-Oklestkova, Barbora Slavikova

Index: Steroids 75(12) , 1005-10, (2010)

Full Text: HTML

Abstract

Androstane brassinosteroid analogues with alpha-azido acid ester groups in position 17beta were synthesized from 2alpha,3alpha,17beta-trihydroxy-5alpha-androstan-6-one after the protection of the 2alpha,3alpha-diols upon treatment with the corresponding alpha-azido acid and the subsequent deprotection of the diol grouping. Six new castasterone analogues were prepared. The biological activities were evaluated in two bioassays: a rice lamina inclination test and bean second internode bioassays. The activities of the new analogues differ in these two bioassays.Copyright 2010 Elsevier Inc. All rights reserved.

Related Compounds

  • 5a-androstane

Related Articles:

Potent and selective steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 7, an enzyme that catalyzes the reduction of the key hormones estrone and dihydrotestosterone.

2009-12-10

[J. Med. Chem. 52 , 7488-502, (2009)]

Novel and efficient synthesis and antifungal evaluation of 2,3-functionalized cholestane and androstane derivatives

2008-01-01

[Bioorg. Med. Chem. Lett. 20 , 7372-5, (2010)]

[Bioconversion of C19- and C21-steroids with parent and mutant strains of Curvularia lunata].

2010-01-01

[Prikl. Biokhim. Mikrobiol. 46(2) , 212-20, (2010)]

Synthesis, antiproliferative activity, acute toxicity and assessment of the antiandrogenic activities of new androstane derivatives.

2011-07-01

[Arch. Pharm. Res. 34(7) , 1055-63, (2011)]

Synthesis, characterization and biological evaluation of some 16E-arylidene androstane derivatives as potential anticancer agents

2011-01-01

[Steroids 76(7) , 709-23, (2011)]

More Articles...