Photodiagnosis and Photodynamic Therapy 2012-06-01

Evaluation of collagen alteration after topical photodynamic therapy (PDT) using second harmonic generation (SHG) microscopy--in vivo study in a mouse model.

Ting Lv, Zu-Fang Huang, Hong-Wei Wang, Ju-Qiang Lin, Guan-Nan Chen, Xi-Wen Chen, Rong Chen, Zheng Huang, Xiu-Li Wang

Index: Photodiagnosis Photodyn. Ther. 9(2) , 164-9, (2012)

Full Text: HTML

Abstract

Topical photodynamic therapy (PDT) mediated by 5-aminolevulinic acid (ALA) has been used for the treatment of age-related skin lesions for therapeutic or cosmetic purposes. The modulation of collagen component and structure might play a significant role in influencing treatment outcomes of PDT. In this study, the effect of multi-session low dose ALA PDT on skin rejuvenation was examined in a hairless mouse model. Changes in collagen and skin texture were investigated by histological examination and in vivo second harmonic generation (SHG) microscopy. Results indicated that multi-session PDT could improve the collagen density and arrangement of skin tissue. SHG microscopy combined with quantitative collagen analysis could provide a useful tool for the evaluation of collagen alteration induced by ALA PDT.Copyright © 2011 Elsevier B.V. All rights reserved.

Related Compounds

  • 5-Aminovaleric aci...
  • 4-carboxybutan-1-a...

Related Articles:

Peptide dimethylation: fragmentation control via distancing the dimethylamino group.

2014-10-01

[J. Am. Soc. Mass Spectrom. 25(10) , 1694-704, (2014)]

Detection of autosomal dominant polycystic kidney disease by NMR spectroscopic fingerprinting of urine.

2011-06-01

[Kidney Int. 79(11) , 1244-53, (2011)]

Highly sensitive GC/MS/MS method for quantitation of amino and nonamino organic acids.

2011-04-01

[Anal. Chem. 83(7) , 2705-11, (2011)]

Differential 12C-/13C-isotope dansylation labeling and fast liquid chromatography/mass spectrometry for absolute and relative quantification of the metabolome.

2009-05-15

[Anal. Chem. 81(10) , 3919-32, (2009)]

Development of imidazole alkanoic acids as mGAT3 selective GABA uptake inhibitors.

2011-05-01

[Eur. J. Med. Chem. 46 , 1483-98, (2011)]

More Articles...