Synthesis and structural study of cyclic 5-aminovaleric acid-linked beta-Ala-beta-Ala dipeptides.
Anne Mengel, Oliver Reiser, Jeffrey Aubé
Index: Bioorg. Med. Chem. Lett. 18(22) , 5975-7, (2008)
Full Text: HTML
Abstract
5-Aminovaleric acid and ornithine were evaluated as linkers for the cyclization of beta-dipeptides. Two linked examples of beta-Ala-beta-Ala were prepared by standard coupling methods and their conformations probed by NMR, CD, and computational means. The data suggest that these non- or monosubstituted versions of the target compounds are flexible in solution.
Related Compounds
Related Articles:
2014-10-01
[J. Am. Soc. Mass Spectrom. 25(10) , 1694-704, (2014)]
2011-06-01
[Kidney Int. 79(11) , 1244-53, (2011)]
2011-04-01
[Anal. Chem. 83(7) , 2705-11, (2011)]
2009-05-15
[Anal. Chem. 81(10) , 3919-32, (2009)]
2011-05-01
[Eur. J. Med. Chem. 46 , 1483-98, (2011)]