Synthesis, DNA binding and antileishmanial activity of low molecular weight bis-arylimidamides

M Banerjee, AA Farahat, A Kumar, T Wenzler…

Index: Banerjee, Moloy; Farahat, Abdelbasset A.; Kumar, Arvind; Wenzler, Tanja; Brun, Reto; Munde, Manoj M.; Wilson, W. David; Zhu, Xiaohua; Werbovetz, Karl A.; Boykin, David W. European Journal of Medicinal Chemistry, 2012 , vol. 55, p. 449 - 454

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Citation Number: 9

Abstract

The effects of reducing the molecular weight of the antileishmanial compound DB766 on DNA binding affinity, antileishmanial activity and cytotoxicity are reported. The bis- arylimidamides were prepared by the coupling of aryl S-(2-naphthylmethyl) thioimidates with the corresponding amines. Specifically, we have prepared new series of bis-arylimidamides which include 3a, 3b, 6, 9a, 9b, 9c, 13, and 18. Three compounds 9a, 9c, and 18 bind to ...

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