4-(4-aminophenyl)aniline

Modify Date: 2026-07-03 10:15:43

4-(4-aminophenyl)aniline structure	Common Name	4-(4-aminophenyl)aniline
	CAS Number	92-87-5	Molecular Weight	184.237
	Density	1.2±0.1 g/cm3	Boiling Point	402°C
	Molecular Formula	C₁₂H₁₂N₂	Melting Point	127-128 °C
	MSDS	Chinese USA	Flash Point	11 °C
	Symbol	GHS02, GHS06, GHS08, GHS09	Signal Word	Danger

Summary: 4-(4-aminophenyl)aniline, also known as联苯胺, CAS number 92-87-5, has a molecular formula of C12H12N2 and a molecular weight of 184.237. It appears as a gray-white solid with a melting point of 127-128°C, boiling point of 402°C, and a density of 1.2±0.1 g/cm3. Used for manufacturing dyes such as direct dyes, acidic dyes, and reducing dyes, as well as for colorimetric determination of oxidants. For research-use only, not for medical or clinical usage.

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	4-(4-aminophenyl)aniline
Synonym	More Synonyms

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.2±0.1 g/cm3
Boiling Point	402°C
Melting Point	127-128 °C
Molecular Formula	C₁₂H₁₂N₂
Molecular Weight	184.237
Flash Point	11 °C
Exact Mass	184.100052
PSA	52.04000
LogP	1.56
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.667
InChIKey	HFACYLZERDEVSX-UHFFFAOYSA-N
SMILES	Nc1ccc(-c2ccc(N)cc2)cc1
Stability	Stable. Combustible. Incompatible with strong oxidizing agents.
Water Solubility	Sparingly soluble.

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

4-(4-aminophenyl)aniline MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DC9625000

CHEMICAL NAME :: Benzidine

CAS REGISTRY NUMBER :: 92-87-5

BEILSTEIN REFERENCE NO. :: 0742770

LAST UPDATED :: 199806

DATA ITEMS CITED :: 121

MOLECULAR FORMULA :: C12-H12-N2

MOLECULAR WEIGHT :: 184.26

WISWESSER LINE NOTATION :: ZR DR DZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 309 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 214 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 110 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 17600 ug/m3/14Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - hematuria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 108 mg/kg/27D-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 mg/m3/56W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Blood - leukemia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1200 mg/kg/26W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intratracheal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 315 mg/kg/34W

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8400 mg/kg/35W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 75 mg/kg/3Y-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1620 gm/kg/45W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 850 mg/kg/32W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Skin and Appendages - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 800 mg/kg/60W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Ear) - effect, not otherwise specified Blood - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2025 mg/kg/27W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Ear) - effect, not otherwise specified Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 25560 ng/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Sister chromatid exchange

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: DNA damage

TYPE OF TEST :: DNA adduct

TYPE OF TEST :: DNA damage

TYPE OF TEST :: Unscheduled DNA synthesis

TYPE OF TEST :: DNA inhibition

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: DNA damage

TYPE OF TEST :: DNA adduct

TYPE OF TEST :: DNA inhibition

TYPE OF TEST :: DNA inhibition

TYPE OF TEST :: Mutation test systems - not otherwise specified

TYPE OF TEST :: Mutation test systems - not otherwise specified

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Sister chromatid exchange

TYPE OF TEST :: DNA adduct

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Rodent - rabbit Liver

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 43,3120,1983 *** REVIEWS *** ACGIH TLV-Confirmed human carcinogen (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Human Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 1,80,1972 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 1,80,1972 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 29,149,1982 IARC Cancer Review:Human Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 29,149,1982 IARC Cancer Review:Group 1 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,123,1987 TOXICOLOGY REVIEW EAHB** Environmental and Health Criteria for Benzidine. Meeting of DHEW Committee to Coordinate Toxicology and Related Programs, Feb. 15, 1974 at Sterling Forest, NY Volume(issue)/page/year: -,38,1974 TOXICOLOGY REVIEW KHZHAZ Khimiya i Zhizn. Chemistry and Life. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1965- Volume(issue)/page/year: 12(2),85,1976 TOXICOLOGY REVIEW ADCSAJ Advances in Chemistry Series. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) No.1- 1950- Volume(issue)/page/year: 13,271,1970 TOXICOLOGY REVIEW BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New York, NY 10003) V.1- 1973- Volume(issue)/page/year: 24,253,1983 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD:skin-HUMAN CARCINOGEN, NO ASSIGNED TWA DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8. Volume(issue)/page/year: 3,11,1973 OSHA PEL (Gen Indu):see CFR 29,1910.1010 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):see CFR 29,1926.1110 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926,55,1994 OSHA PEL (Shipyard):see CFR 29,1915.1010 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA-cancer suspect agent CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1010,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA;(Prohibited) Skin;Carcinogen JAN 1993 OEL-FINLAND;Carcinogen JAN 1993 OEL-FRANCE:TWA 0.001 ppm (0.008 mg/m3);Carcinogen JAN 1993 OEL-GERMANY;Skin;Carcinogen JAN 1993 OEL-THE NETHERLANDS;Skin JAN 1993 OEL-SWEDEN;Carcinogen JAN 1993 OEL-SWITZERLAND;Carcinogen JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO BENZIDINE-air:CA use 29 CFR 1910.1010 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 09830 No. of Facilities: 263 (estimated) No. of Industries: 4 No. of Occupations: 5 No. of Employees: 1166 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 09830 No. of Facilities: 252 (estimated) No. of Industries: 3 No. of Occupations: 8 No. of Employees: 1554 (estimated) No. of Female Employees: 426 (estimated)

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol	GHS02, GHS06, GHS08, GHS09
Signal Word	Danger
Hazard Statements	H225-H301 + H311 + H331-H350-H370-H411
Precautionary Statements	P201-P210-P260-P280-P301 + P310 + P330-P370 + P378
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T:Toxic;N:Dangerousfortheenvironment;
Risk Phrases	R45;R22;R50/53
Safety Phrases	S53-S45-S60-S61-S36/37-S16-S7
RIDADR	UN 1885 6.1/PG 2
WGK Germany	3
RTECS	DC9625000
Packaging Group	II
Hazard Class	6.1(a)
HS Code	2921590020

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 9
CAS#:1528-74-1 4,4'-Dinitrobiphenyl CAS#:106-40-1 4-Bromoaniline CAS#:106-47-8 4-Chloroaniline CAS#:92-86-4 4,4'-Dibromobiphenyl
CAS#:540-37-4 4-Iodoaniline CAS#:122-66-7 1,2-Diphenylhyd... CAS#:3001-15-8 4,4'-Diiodobiphenyl CAS#:1227476-15-4 1,2-diphenyldiazene
CAS#:7440-66-6 Zinc
DownStream 10
CAS#:5730-78-9 4'-Amino-4-biph... CAS#:4854-84-6 4-Amino-4'-cyan... CAS#:398-23-2 4,4'-Difluorobi... CAS#:366-29-0 N,N,N',N'-TETRA...
CAS#:92-86-4 4,4'-Dibromobiphenyl CAS#:92-88-6 4,4'-Dihydroxyb... CAS#:206182-66-3 (4'-AMINO-BIPHE... CAS#:97-02-9 2,4-Dinitroaniline
CAS#:787-69-9 4,4'-Diacetylbi... CAS#:2761-22-0 1,1'-Biphenyl,4...

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2921590020
Summary	2921590020 benzidine。supervision conditions:89(articles on the list of prohibited export goods,articles on the list of prohibited import goods)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:30.0%

This table lists relevant public references with title, journal and publication metadata for this compound.

Design and synthesis of a cell-permeable, drug-like small molecule inhibitor targeting the polo-box domain of polo-like kinase 1.

PLoS ONE 9(9) , e107432, (2014)

Polo-like kinase-1 (Plk1) plays a crucial role in cell proliferation and the inhibition of Plk1 has been considered as a potential target for specific inhibitory drugs in anti-cancer therapy. Several ...

Convenient QSAR model for predicting the complexation of structurally diverse compounds with β-cyclodextrins

Bioorg. Med. Chem. 17 , 896-904, (2009)

This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoret...

Adhesive and migratory effects of phosphophoryn are modulated by flanking peptides of the integrin binding motif.

PLoS ONE 9(11) , e112490, (2014)

Phosphophoryn (PP) is generated from the proteolytic cleavage of dentin sialophosphoprotein (DSPP). Gene duplications in the ancestor dentin matrix protein-1 (DMP-1) genomic sequence created the DSPP ...

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

BENZIDINE

4,4'-Bianiline

p-Diaminodiphenyl

biphenyl-4,4'-diamine

EINECS 202-199-1

4,4'-Diaminobiphenyl

4,4'-Diaminodiphenyl

Fast Corinth Base B

4,4'-Biphenyldiamine

p,p'-diaminobiphenyl

MFCD00143662

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What are the upstream materials of 4-(4-aminophenyl)aniline?

A: Related upstream materials(CAS) of 4-(4-aminophenyl)aniline: 1528-74-1;106-40-1;106-47-8;92-86-4;540-37-4;122-66-7;3001-15-8;1227476-15-4;7440-66-6.

Q: What is the InChIKey of 4-(4-aminophenyl)aniline?

A: InChIKey of 4-(4-aminophenyl)aniline is HFACYLZERDEVSX-UHFFFAOYSA-N.

Q: What is the molecular weight of 4-(4-aminophenyl)aniline?

A: Molecular weight of 4-(4-aminophenyl)aniline is 184.237.

Q: What English synonyms does 4-(4-aminophenyl)aniline have?

A: English synonyms of 4-(4-aminophenyl)aniline: BENZIDINE, 4,4'-Bianiline, p-Diaminodiphenyl, biphenyl-4,4'-diamine, EINECS 202-199-1, 4,4'-Diaminobiphenyl, 4,4'-Diaminodiphenyl, Fast Corinth Base B, 4,4'-Biphenyldiamine, p,p'-diaminobiphenyl, MFCD00143662.

Q: What is the English name of 4-(4-aminophenyl)aniline?

A: The English name of 4-(4-aminophenyl)aniline is 4-(4-aminophenyl)aniline.

Q: What is the melting point of 4-(4-aminophenyl)aniline?

A: Melting point of 4-(4-aminophenyl)aniline is 127-128 °C.

Q: What is the molecular formula of 4-(4-aminophenyl)aniline?

A: Molecular formula of 4-(4-aminophenyl)aniline is C12H12N2.

Q: What is the boiling point of 4-(4-aminophenyl)aniline?

A: Boiling point of 4-(4-aminophenyl)aniline is 402°C.

Q: What is the SMILES notation of 4-(4-aminophenyl)aniline?

A: SMILES notation of 4-(4-aminophenyl)aniline is Nc1ccc(-c2ccc(N)cc2)cc1.

Q: What are the downstream products of 4-(4-aminophenyl)aniline?

A: Related downstream products(CAS) of 4-(4-aminophenyl)aniline: 5730-78-9;4854-84-6;398-23-2;366-29-0;92-86-4;92-88-6;206182-66-3;97-02-9;787-69-9;2761-22-0.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Henan Tianfu Chemical Co., Ltd.

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 4-(4-aminophenyl)aniline
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Benzidine
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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4-(4-aminophenyl)aniline

Names

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

Synthetic Route

Precursor & DownStream

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Synonyms

4-(4-aminophenyl)aniline | FAQ

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