Organic Letters 2001-03-08

An approach to the skeleton of the securinega alkaloids. The total synthesis of (+/-)-securinine.

S Liras, J E Davoren, J Bordner

Index: Org. Lett. 3(5) , 703-6, (2001)

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Abstract

[structure: see text]. The concise total synthesis of securinine in nine steps from readily available starting materials is described. Key steps of the synthesis include an addition of a silyloxyfuran to an in situ generated iminium ion and a novel ring closing metathesis reaction.

Related Compounds

  • Securinine

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