Securinine
Securinine structure
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Common Name | Securinine | ||
|---|---|---|---|---|
| CAS Number | 5610-40-2 | Molecular Weight | 217.264 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 459.0±45.0 °C at 760 mmHg | |
| Molecular Formula | C13H15NO2 | Melting Point | 140-142ºC | |
| MSDS | Chinese USA | Flash Point | 197.0±19.6 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Proteomic and systems biology analysis of monocytes exposed to securinine, a GABA(A) receptor antagonist and immune adjuvant.
PLoS ONE 7(9) , e41278, (2012) Securinine, a GABA(A) receptor antagonist, has been reported to enhance monocyte cell killing of Coxiella burnetii without obvious adverse effects in vivo. We employed multiplex 2D gel electrophoresis using Zdyes, a new generation of covalently linked fluores... |
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Securinine, a myeloid differentiation agent with therapeutic potential for AML.
PLoS ONE 6(6) , e21203, (2011) As the defining feature of Acute Myeloid Leukemia (AML) is a maturation arrest, a highly desirable therapeutic strategy is to induce leukemic cell maturation. This therapeutic strategy has the potential of avoiding the significant side effects that occur with... |
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L-securinine induced the human colon cancer SW480 cell autophagy and its molecular mechanism.
Fitoterapia 82(8) , 1258-64, (2011) To investigate the anti-tumor effects of L-securinine inducing colon cancer SW480 cell autophagy and explore its potential molecular mechanism.MTT method was used to detect the antitumor effect of SW480 cells cultured with L-securinine in vitro. Light and ele... |
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Intracellular calcium involved in the long-term potentiation induced by securinine in dentate gyrus of anesthetized rats.
Planta Med. 68(8) , 752-3, (2002) The effect of nimodipine on securinine-induced long-term potentiation in rat hippocampus was studied. The rise of intracellular calcium during the induction of long-term potentiation was measured using Fura-2/AM--a Ca (2+) fluorescent chelator. Results showed... |
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Securinega suffruticosa.
Fitoterapia 79(6) , 419-27, (2008) This review gives an account of the current knowledge on the chemical constituents, biological activity and pharmacological properties of Securinega suffruticosa. A wide range of chemical compounds have been isolated, mainly alkaloids, flavonoids, tannins and... |
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Callus of Securinega suffruticosa, a cell line accumulates dextro Securinega alkaloids.
Nat. Prod. Res. 21(3) , 234-42, (2007) Investigations on callus cultures of Securinega suffruticosa indicated that the cell line of S. suffruticosa callus was able to accumulate four known Securinega alkaloids with dextro rotation but not levo rotation as reported before: virosecurinine (1), viroa... |
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Newly detected specific hydrogenation of the conjugated double bond of unsaturated alkaloid lactones by Aspergillus sp.
Biotechnol. Lett. 27(16) , 1189-93, (2005) A new isolate of Aspergillus sp. hydrogenated the gamma,delta-double bond of securinine (143 mg l(-1)) to give 14,15-dihydrosecurinine at over 98% (w/w) yield after 8 h. It also hydrogenated the C11(13) double bond of 3-hydroxy-1(10),3,11(13)-guaiatriene-12,6... |
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Toxoplasma gondii: inhibitory activity and encystation effect of securinine and pyrrolidine derivatives on Toxoplasma growth.
Exp. Parasitol. 127(2) , 370-5, (2011) Securinine, an alkaloid originally isolated from Securinega suffruticosa, exhibits a wide range of biological activities, including anti-malarial activity. Along with securinine, 10 pyrrolidine derivatives, generated via the retrosynthesis of (-)-securinine, ... |
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Neuroprotection by D-securinine against neurotoxicity induced by beta-amyloid (25-35).
Neurol. Res. 26(7) , 792-6, (2004) The effects of (+) securinine on behavior and morphological changes after intracerebral ventricle injection of beta-amyloid (25-35) (Abeta(25-35)) in rats were investigated. A single high dose of Abeta(25-35) could impair the spatial cognitive function. The l... |
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An approach to the skeleton of the securinega alkaloids. The total synthesis of (+/-)-securinine.
Org. Lett. 3(5) , 703-6, (2001) [structure: see text]. The concise total synthesis of securinine in nine steps from readily available starting materials is described. Key steps of the synthesis include an addition of a silyloxyfuran to an in situ generated iminium ion and a novel ring closi... |