Journal of the American Chemical Society

Diuretics. I. 3-Substituted paraxanthines

FF Blicke, HC Godt Jr

Index: Blicke; Godt Journal of the American Chemical Society, 1954 , vol. 76, p. 3653

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Citation Number: 23

Abstract

It was found that the necessary paraxanthine (V) could be obtained in adequate amounts by the following eight-ster, process. Diethyl oxalate was converted by methylamine into N, N'- dimethyloxamide (I) in the manner described by Mrallach. 3~ 4 The amide reacted with phosphorus pentachloride to yield 1-methyl-5-chleroimidazole (11). This reaction has been described inadequately by Wal-