Journal of Pharmacological Sciences (Print Edition) 2009-10-01

A selective thromboxane A2 (TXA2) synthase inhibitor, ozagrel, attenuates lung injury and decreases monocyte chemoattractant protein-1 and interleukin-8 mRNA expression in oleic acid-induced lung injury in guinea pigs.

Yoichi Ishitsuka, Hiroshi Moriuchi, Yoichiro Isohama, Hidehiro Tokunaga, Keita Hatamoto, Sumika Kurita, Mitsuru Irikura, Ken-ichi Iyama, Tetsumi Irie

Index: J. Pharmacol. Sci. 111(2) , 211-5, (2009)

Full Text: HTML

Abstract

This study examined the effect of ozagrel, a thromboxane A(2) synthase inhibitor, on the accumulation of leucocytes and chemokine mRNA expression in lungs experimentally injured using oleic acid (OA). OA injection into guinea pigs rapidly increased thromboxane A(2) generation and subsequently increased total protein concentration and the numbers of macrophages and neutrophils in bronchoalveolar lavage fluid and increased monocyte chemoattractant protein-1 and interleukin-8 mRNA expression in the whole lung. Administration of ozagrel prevented these changes associated with OA injection. Ozagrel is a promising drug candidate for preventing acute lung injury.

Related Compounds

  • Ozagrel hydrochlor...

Related Articles:

Adhesion of platelets through thromboxane A₂ receptor signaling facilitates liver repair during acute chemical-induced hepatotoxicity.

2015-07-01

[Life Sci. 132 , 85-92, (2015)]

BLT2 up-regulates interleukin-8 production and promotes the invasiveness of breast cancer cells.

2012-01-01

[PLoS ONE 7 , e49186, (2012)]

Safety and efficacy of fasudil monotherapy and fasudil-ozagrel combination therapy in patients with subarachnoid hemorrhage: sub-analysis of the post-marketing surveillance study.

2008-06-01

[Neurol. Med. Chir. (Tokyo) 48(6) , 241-7; discussion 247-8, (2008)]

A prostacyclin agonist with thromboxane inhibitory activity for airway allergic inflammation in mice.

2010-02-01

[Clin. Exp. Allergy 40(2) , 317-26, (2010)]

Abnormalities of endothelium-dependent responses in mesenteric arteries from Otsuka Long-Evans Tokushima Fatty (OLETF) rats are improved by chronic treatment with thromboxane A2 synthase inhibitor.

2009-07-01

[Atherosclerosis 205(1) , 87-95, (2009)]

More Articles...