Journal of Combinatorial Chemistry 2009-01-01

New one-pot four-component synthesis of disubstituted pyrido[2,3-d]pyrimidine-6-carboxamide derivatives.

Ahmad Shaabani, Mozhdeh Seyyedhamzeh, Ali Maleki, Fahimeh Rezazadeh, Maryam Behnam

Index: J. Comb. Chem. 11(3) , 375-7, (2009)

Full Text: HTML

Abstract

In this work, 1,2,3,4,5,8-hexahydro-1,3,7-trimethyl-2,4-dioxopyrido[2,3-d]pyrimidine-6-carboxamide derivatives were synthesized in a simple and efficient method from the four-component condensation reaction of diketene, an aliphatic or aromatic amine, an aromatic aldehyde, and 6-amino-1,3-dimethyluracil in the presence of a catalytic amount of p-toluenesulfonic acid under mild conditions at ambient temperature in high yields.

Related Compounds

  • Diketene

Related Articles:

Chemical reactivity and biological activity of diketene.

2008-10-01

[Chem. Res. Toxicol. 21(10) , 1964-9, (2008)]

Novel approach to 1,5-benzodiazepine-2-ones containing peptoid backbone via one-pot diketene-based Ugi-4CR.

2010-07-12

[J. Comb. Chem. 12(4) , 497-502, (2010)]

One-pot multicomponent synthesis of 1-aryl-5-methyl-N-R2-1H-1,2,3-triazole-4-carboxamides: an easy procedure for combinatorial chemistry.

2009-01-01

[J. Comb. Chem. 11(3) , 481-5, (2009)]

Interactions between earthworm hemolysins and sheep red blood cell membranes.

1989-08-07

[Biochim. Biophys. Acta 983(2) , 193-8, (1989)]

Bisaryldiketene derivatives: A new class of selective ligands for c-myc G-quadruplex DNA.

2010-12-01

[Bioorg. Med. Chem. 18(23) , 8235-42, (2010)]

More Articles...