Archiv der Pharmazie (Weinheim) 2001-05-01

Synthesis, physicochemical characterization, and cytotoxic screening of new zirconium complexes with coumarin derivatives.

I Kostova, I Manolov, M Karaivanova

Index: Arch. Pharm. (Weinheim) 334(5) , 157-62, (2001)

Full Text: HTML

Abstract

Zirconium complexes of mendiaxon, warfarin, coumachlor, and niffcoumar have been synthesized by reaction of the ligands with zirconium chloride in stoichiometric ratio 1:2. The formation of the complexes has been proved on the basis of elemental analysis, IR-spectroscopy, 1H-NMR spectroscopy, and thermal studies. Differential thermal analyses and thermogravimetric analyses have been applied to study the compositions of the new complexes. It is concluded that the lactone- and the keto-carbonyl groups of warfarin, coumachlor, and niffcoumar are bonded to the metal ion as bidentate ligands, but mendiaxon is bonded as monodentate ligand. Cytotoxic screening by MTT-assay was carried out. Among these compounds the zirconium complex of mendiaxon showed highest cytotoxic activity against human promyelocytic leukemic HL-60 cells. The inorganic salt was found to be active against this cell line.

Related Compounds

  • COUMACHLOR

Related Articles:

A chiral separation strategy for acidic drugs in capillary electrochromatography using both chlorinated and nonchlorinated polysaccharide-based selectors.

2014-10-01

[Electrophoresis 35(19) , 2807-18, (2014)]

Single-step approach for fabrication of vancomycin-bonded silica monolith as chiral stationary phase.

2014-09-05

[J. Chromatogr. A. 1358 , 208-16, (2014)]

Toxicology and histopathology of some rodenticides and palatable food items combinations on the common mice Mus musculus var. albus in Egypt.

2003-01-01

[Commun. Agric. Appl. Biol. Sci. 68(4 Pt B) , 771-87, (2003)]

Separation and determination of warfarin enantiomers in human plasma using a novel polymeric surfactant for micellar electrokinetic chromatography-mass spectrometry.

2007-08-03

[J. Chromatogr. A. 1159(1-2) , 208-16, (2007)]

Enantioselective supercritical fluid chromatography using ristocetin A chiral stationary phases.

2000-06-01

[Analyst 125(6) , 1037-9, (2000)]

More Articles...