COUMACHLOR

COUMACHLOR Structure
COUMACHLOR structure
Common Name COUMACHLOR
CAS Number 81-82-3 Molecular Weight 342.773
Density 1.4±0.1 g/cm3 Boiling Point 543.1±50.0 °C at 760 mmHg
Molecular Formula C19H15ClO4 Melting Point 168-170 °C(lit.)
MSDS Chinese USA Flash Point 282.3±30.1 °C
Symbol GHS08
GHS08
Signal Word Warning

A chiral separation strategy for acidic drugs in capillary electrochromatography using both chlorinated and nonchlorinated polysaccharide-based selectors.

Electrophoresis 35(19) , 2807-18, (2014)

A generic chiral separation strategy for the analysis of acidic compounds in CEC is proposed in completion of an earlier defined strategy for nonacidic compounds. The screening step of this strategy uses a 45 mM ammonium formate (pH 2.9)/ACN (35/65, v/v) mobi...

Single-step approach for fabrication of vancomycin-bonded silica monolith as chiral stationary phase.

J. Chromatogr. A. 1358 , 208-16, (2014)

A vancomycin-bonded silica monolithic column for capillary electrochromatography (CEC) was prepared by a single-step in situ sol-gel approach. This sol-gel process incorporates a synthetic sol-gel precursor which contains a macrocyclic antibiotic, vancomycin,...

Toxicology and histopathology of some rodenticides and palatable food items combinations on the common mice Mus musculus var. albus in Egypt.

Commun. Agric. Appl. Biol. Sci. 68(4 Pt B) , 771-87, (2003)

In this study the palatability tests of certain food items as attractants in the poisoned-baits for the albino mouse Mus musculus var. albus showed that the food items of treacle, maize oil, dry or wet sugar and milk powder act as more attractive pleasant mat...

Synthesis, physicochemical characterization, and cytotoxic screening of new zirconium complexes with coumarin derivatives.

Arch. Pharm. (Weinheim) 334(5) , 157-62, (2001)

Zirconium complexes of mendiaxon, warfarin, coumachlor, and niffcoumar have been synthesized by reaction of the ligands with zirconium chloride in stoichiometric ratio 1:2. The formation of the complexes has been proved on the basis of elemental analysis, IR-...

Separation and determination of warfarin enantiomers in human plasma using a novel polymeric surfactant for micellar electrokinetic chromatography-mass spectrometry.

J. Chromatogr. A. 1159(1-2) , 208-16, (2007)

Warfarin is a widely used oral anticoagulant which is mostly administrated as a racemic mixture containing equal amount of R- and S-enantiomers. The two enantiomers are shown to exhibit significant differences in pharmacokinetics and pharmacodynamics. In this...

Enantioselective supercritical fluid chromatography using ristocetin A chiral stationary phases.

Analyst 125(6) , 1037-9, (2000)

Racemic mixtures of five acidic drugs have been successfully separated by supercritical fluid chromatography (SFC) using macrocyclic antibiotic chiral stationary phases (CSPs). A ristocetin A CSP has been prepared 'in-house' and effectively applied in packed ...

Brush-type chiral stationary phase for enantioseparation of acidic compounds. Optimization of chiral capillary electrochromatographic parameters.

J. Chromatogr. A. 1005(1-2) , 177-87, (2003)

The capillary electrochromatographic separations of three acidic enantiomers (carprofen, coumachlor and warfarin) were studied on a capillary column packed with 5 microm (3R,4S)-Whelk-O 1 chiral stationary phase. The influence of several experimental paramete...

Achiral and chiral separations using MEKC, polyelectrolyte multilayer coatings, and mixed mode separation techniques with molecular micelles.

Electrophoresis 31(6) , 1036-43, (2010)

Mixed mode (MM) separation using a combination of MEKC and polyelectrolyte multilayer (PEM) coatings is herein reported for the separation of achiral and chiral analytes. Many analytes are difficult to separate by MEKC and PEM coatings alone. Therefore, the i...

Characterization of warfarin unusual peak profiles on oligoproline chiral high performance liquid chromatography columns.

J. Chromatogr. A. 1217(42) , 6545-54, (2010)

Unusual peak profiles of warfarin were characterized on two oligoproline chiral stationary phases (CSPs). The pattern of 1st peak (S(-)) broadening and the 2nd peak (R(+)) compression was observed under mobile phase of hexane (0.1% TFA)/2-propanol (IPA) on a ...