Annales d'Endocrinologie 1999-07-01

Mechanism of GnRH receptor signaling: from the membrane to the nucleus.

S Shacham, M N Cheifetz, H Lewy, I E Ashkenazi, O M Becker, R Seger, Z Naor

Index: Ann. Endocrinol. 60 , 79-88, (1999)

Full Text: HTML

Abstract

The purpose of this review is to update the information concerning the intracellular effect of GnRH. Binding of GnRH to a G-protein coupled receptor leads to stimulation of Gq and/or G11 protein and to activation of phospholipase C beta. Inositol 1-4-5-triphosphate and early diacylylycerol are the second messengers required for conventional protein kinase C activation. Activation of phospholipase A2 and phospholipase D are also involved, as demonstrated by the liberation of Arachidonic Acid and Phosphatidic Acid. Pituitary cells also express atypical protein kinase C isoforms which mode of activation is not known. Hypothesis concerning transcriptional regulation are presented.

Related Compounds

  • Gonadorelin diacet...
  • LHRH (salmon) ac...

Related Articles:

Reduced melanocortin production causes sexual dysfunction in male mice with POMC neuronal insulin and leptin insensitivity.

2015-04-01

[Endocrinology 156(4) , 1372-85, (2015)]

Developmental programming: impact of prenatal testosterone excess on pre- and postnatal gonadotropin regulation in sheep.

2008-04-01

[Biogerontology 78 , 648-60, (2008)]

GnRH receptor and apoptotic signaling.

2000-01-01

[Vitam. Horm. 59 , 1-33, (2000)]

Pituitary and extrapituitary actions of gonadotrophin-releasing hormone and its analogues.

1999-09-01

[Hum. Reprod. 14 , 194-206, (1999)]

An inducible offense: carnivore morph tadpoles induced by tadpole carnivory.

2015-04-01

[Ecol. Evol. 5(7) , 1405-11, (2015)]

More Articles...