Chemical Communications 2008-02-21

Facile synthesis of 3-(aminomethyl)isoquinolines by copper-catalysed domino four-component coupling and cyclisation.

Yusuke Ohta, Shinya Oishi, Nobutaka Fujii, Hiroaki Ohno

Index: Chem. Commun. (Camb.) (7) , 835-7, (2008)

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Abstract

Copper(i)-catalysed domino four-component coupling-cyclisation using 2-ethynylbenzaldehydes, paraformaldehyde, secondary amine, and t-BuNH(2) in DMF leads to direct and efficient formation of 3-(aminomethyl)isoquinolines in good to high yields.