2,4,6-Trimethoxybenzylamine hydrochloride

2,4,6-Trimethoxybenzylamine hydrochloride Structure
2,4,6-Trimethoxybenzylamine hydrochloride structure
Common Name 2,4,6-Trimethoxybenzylamine hydrochloride
CAS Number 146548-59-6 Molecular Weight 233.692
Density 1.087g/cm3 Boiling Point 312ºC at 760mmHg
Molecular Formula C10H16ClNO3 Melting Point 204-207 °C(lit.)
MSDS Chinese USA Flash Point 151.1ºC
Symbol GHS07
GHS07
Signal Word Warning

Facile synthesis of 3-(aminomethyl)isoquinolines by copper-catalysed domino four-component coupling and cyclisation.

Chem. Commun. (Camb.) (7) , 835-7, (2008)

Copper(i)-catalysed domino four-component coupling-cyclisation using 2-ethynylbenzaldehydes, paraformaldehyde, secondary amine, and t-BuNH(2) in DMF leads to direct and efficient formation of 3-(aminomethyl)isoquinolines in good to high yields.