Archives of Environmental and Occupational Health 1985-01-01

Subchronic oral toxicity of tributoxyethyl phosphate in the Sprague-Dawley rat.

S Laham, B R Broxup, G W Long

Index: Arch. Environ. Health 40(1) , 12-7, (1985)

Full Text: HTML

Abstract

The effects of the widely used alkyl phosphate, tributoxyethyl phosphate (TBOP), were investigated in male and female Sprague-Dawley rats. This chemical was administered (low dose: 0.25 ml/kg X day; high dose: 0.50 ml/kg X day) by gavage once a day for 5 days/wk, over a period of 18 wk. Histopathological examination of tissues in treated male rats showed the presence of cardiac lesions, including myocardial necrosis with inflammatory cell infiltration. This study indicated that oral administration of TBOP may have caused or contributed to the early onset of a common background finding in this rat strain.

Related Compounds

  • Tris(2-butoxyethyl...

Related Articles:

Elucidating toxicological mechanisms of current flame retardants using a bacterial gene profiling assay.

2015-12-01

[Toxicol. In Vitro 29 , 2124-32, (2015)]

Organophosphate flame retardants and organosiloxanes in predatory freshwater fish from locations across Canada.

2014-10-01

[Environ. Pollut. 193 , 254-61, (2014)]

Levels and distributions of organophosphate flame retardants and plasticizers in sediment from Taihu Lake, China.

2012-07-01

[Environ. Toxicol. Chem. 31(7) , 1478-84, (2012)]

Estimation of tris(2-butoxyethyl) phosphate in biological fluids: novel intersubject variability in recovery from human serum.

1984-12-01

[J. Pharm. Sci. 73(12) , 1791-3, (1984)]

In vitro endocrine disruption potential of organophosphate flame retardants via human nuclear receptors.

2013-12-06

[Toxicology 314(1) , 76-83, (2013)]

More Articles...