2-[(Arylmethyl) amino]-2-methyl-1, 3-propanediol DNA intercalators. An examination of the effects of aromatic ring variation on antitumor activity and DNA binding

…, RL Tuttle, VC Knick, M Cory, DD McKee

Index: Bair; Andrews; Tuttle; Knick; Cory; McKee Journal of Medicinal Chemistry, 1991 , vol. 34, # 7 p. 1983 - 1990

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Citation Number: 45

Abstract

The effects of variation of aromatic ring size, shape, and side-chain position on antitumor activity and DNA bin-in a series of carbocyclic 2-[(arylmethyl) amino]-2-methyl-l, 3-propan@ ols (AMAPs) were examined. In general, the interaction of AMAPs with DNA increases as the intercalating ring system grows in area, with three distinct binding levels evident. Isomers from a specific ring system appear to bind DNA similarly. DNA binding is not the sole ...

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