Clinical Autonomic Research 2008-06-01

Activation of peripheral opioid receptors has no effect on heart rate variability.

Ender Ellidokuz, Dayimi Kaya, Ihsan Uslan, Ataç Celik, Ali Metin Esen, Irfan Barutça

Index: Clin. Auton. Res. 18(3) , 145-9, (2008)

Full Text: HTML

Abstract

Opioid receptors involved in regulating the motility of the gastrointestinal tract have been localized in both contractile and neuronal tissues. Trimebutine, a peripheral opioid receptor agonist, modulates gastrointestinal motor activity in both directions and also may act on cardiac tissue. This study investigated the effects of trimebutine in clinical doses on cardiac autonomic functions with heart rate variability. The effect of trimebutine on cardiac autonomic outflows was evaluated in 11 healthy subjects. Trimebutine (200 mg) or placebo was administered orally at random in a double-blind, cross-over manner. Continuous electrocardiography recordings were obtained before and after drug administration during three states: rest, controlled breathing, and a hand grip exercise. Heart rate variability analysis showed that there was no significant difference between subjects administered with placebo or trimebutine throughout rest, controlled breathing, or the hand grip exercise. We concluded that trimebutine, in clinical doses, has no significant effect on cardiac autonomic functions.

Related Compounds

  • Trimebutine

Related Articles:

Safety, tolerability and pharmacokinetics of trimebutine 3-thiocarbamoylbenzenesulfonate (GIC-1001) in a randomized phase I integrated design study: single and multiple ascending doses and effect of food in healthy volunteers.

2014-11-01

[Clin. Ther. 36(11) , 1650-64, (2014)]

[Prokinetics in childhood].

2010-06-01

[Arch. Pediatr. 17(6) , 737-8, (2010)]

Effectiveness of trimebutine maleate on modulating intestinal hypercontractility in a mouse model of postinfectious irritable bowel syndrome.

2010-06-25

[Eur. J. Pharmacol. 636(1-3) , 159-65, (2010)]

Inhibitory effects of ramosetron, a potent and selective 5-HT3-receptor antagonist, on conditioned fear stress-induced abnormal defecation and normal defecation in rats: comparative studies with antidiarrheal and spasmolytic agents.

2008-02-01

[J. Pharmacol. Sci. 106(2) , 264-70, (2008)]

Novelty stress increases fecal pellet output in mongolian gerbils: effects of several drugs.

2005-08-01

[J. Pharmacol. Sci. 98(4) , 411-8, (2005)]

More Articles...