Trimebutine
Trimebutine structure
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Common Name | Trimebutine | ||
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| CAS Number | 39133-31-8 | Molecular Weight | 387.469 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 457.9±34.0 °C at 760 mmHg | |
| Molecular Formula | C22H29NO5 | Melting Point | 79ºC | |
| MSDS | USA | Flash Point | 230.8±25.7 °C | |
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Safety, tolerability and pharmacokinetics of trimebutine 3-thiocarbamoylbenzenesulfonate (GIC-1001) in a randomized phase I integrated design study: single and multiple ascending doses and effect of food in healthy volunteers.
Clin. Ther. 36(11) , 1650-64, (2014) Trimebutine 3-thiocarbamoylbenzenesulfonate (GIC-1001) is a new drug intended to be used for the management of visceral pain in patients undergoing sedation-free, full colonoscopy. The objectives of this Phase I, single-center, randomized, double-blinded, pla... |
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[Prokinetics in childhood].
Arch. Pediatr. 17(6) , 737-8, (2010)
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Effectiveness of trimebutine maleate on modulating intestinal hypercontractility in a mouse model of postinfectious irritable bowel syndrome.
Eur. J. Pharmacol. 636(1-3) , 159-65, (2010) Trimebutine maleate, which modulates the calcium and potassium channels, relieves abdominal pain in patients with irritable bowel syndrome. However, its effect on postinfectious irritable bowel syndrome is not clarified. The aim of this study was to investiga... |
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Inhibitory effects of ramosetron, a potent and selective 5-HT3-receptor antagonist, on conditioned fear stress-induced abnormal defecation and normal defecation in rats: comparative studies with antidiarrheal and spasmolytic agents.
J. Pharmacol. Sci. 106(2) , 264-70, (2008) We examined the effect of ramosetron, a potent serotonin (5-HT)(3)-receptor antagonist for irritable bowel syndrome with diarrhea, on conditioned fear stress (CFS)-induced defecation and normal (non-stressed) defecation in rats and compared ramosetron with th... |
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Novelty stress increases fecal pellet output in mongolian gerbils: effects of several drugs.
J. Pharmacol. Sci. 98(4) , 411-8, (2005) Stress-induced colonic functional changes have been investigated mainly under conditions involving physical stress, like in the restraint stress model. In this study, we established a new stress-induced defecation model involving the placement of Mongolian ge... |
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Pharmacokinetic and bioequivalence evaluation of two formulations of 100 mg trimebutine maleate (Recutin and Polybutin) in healthy male volunteers using the LC-MS/MS method.
Clin. Chim. Acta 375(1-2) , 69-75, (2007) Trimebutine maleate is a prokinetic agent that acts directly on the smooth muscle of the GI tract. A bioequivalence (BE) study of 2 oral formulations of 100 mg trimebutine maleate (TMB) was carried out in 24 healthy male Korean volunteers according to a cross... |
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Effect of four medications associated with gastrointestinal motility on Oddi sphincter in the rabbit.
Pancreatology 9(5) , 615-20, (2009) Modulatory drugs of gastrointestinal (GI) motility are a possibility for use to relieve the main clinical presentation of sphincter of Oddi (SO) dysfunctions which are not easily distinguished from those occurring in high prevalence functional GI disorders. T... |
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Effects of trimebutine maleate on colonic motility through Ca²+-activated K+ channels and L-type Ca²+ channels.
Arch. Pharm. Res. 34(6) , 979-85, (2011) The effects of trimebutine maleate (TM) on spontaneous contractions of colonic longitudinal muscle were investigated in guinea pigs. The contractile responses of smooth muscle strips were recorded by an isometric force transducer. Membrane and action potentia... |
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End point determination of blending process for trimebutine tablets using principle component analysis (PCA) and partial least squares (PLS) regression.
Arch. Pharm. Res. 35(9) , 1599-607, (2012) This study showed near Infrared (NIR) and Raman spectroscopy with a multivariate calibration approach were very effective to determine blend uniformity end-point. A set of 36 trimebutine samples containing magnesium stearate, stearic acid, colloidal silicon o... |
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Activation of peripheral opioid receptors has no effect on heart rate variability.
Clin. Auton. Res. 18(3) , 145-9, (2008) Opioid receptors involved in regulating the motility of the gastrointestinal tract have been localized in both contractile and neuronal tissues. Trimebutine, a peripheral opioid receptor agonist, modulates gastrointestinal motor activity in both directions an... |