Acta Poloniae Pharmaceutica

KATARZYNA KIEČ-KONONOWICZ", JANINA KAROLAK-WOJCIECHOWSKA

J HANDZLIK

Index: Kiec-Kononowicz, Katarzyna; Karolak-Wojciechowska, Janina; Handzlik, Jadwiga Acta Poloniae Pharmaceutica - Drug Research, 1998 , vol. 55, # 5 p. 381 - 388

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Abstract

Abstract: The series of glycinc dcrivatives of diphenyl or (un) substituted arylidene imidazolones was designed and obtained as potential ligands of the glycine binding sitc of NMDA rcceptors. The compounds were evaluated in vitro for their affinity to the glycine binding site of NMDA receptors using as radioligand f" H–L–689560. Their anticonvulsant activity was estimated in vivo in naxial electroshock seizure (MES) and subcutaneous ...