A broad spectrum anticancer nucleoside with selective toxicity against human colon cells in vitro

JR Shelton, SR Burt, MA Peterson

Index: Shelton, Jadd R.; Burt, Scott R.; Peterson, Matt A. Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 5 p. 1484 - 1487

Full Text: HTML

Citation Number: 16

Abstract

2′, 3′-Bis-O-tert-butyldimethylsilyl-5′-deoxy-5′-[N-(methylcarbamoyl) amino]-N6-(N- phenylcarbamoyl) adenosine, a new member of the N6, 5′-bis-ureidoadenosine class of anticancer nucleosides, is found to exhibit broad spectrum antiproliferative activity. A majority of the cell lines in the NCI-60 are inhibited with an average GI50= 3.13 μM. Selective toxicity against human colon cancer cell lines (COLO 205, HCC-2998, HCT-116, ...

Related Articles:

Adenylate Deaminase (5′??Adenylic Acid Deaminase, AMPDA)??Catalyzed Deamination of 5′??Deoxy??5′??Substituted and 5′??Protected Adenosines: A …

[Ciuffreda, Pierangela; Loseto, Angela; Alessandrini, Laura; Terraneo, Giancarlo; Santaniello, Enzo European Journal of Organic Chemistry, 2003 , # 24 p. 4748 - 4751]

Preliminary SAR analysis of novel antiproliferative N 6, 5′-bis-ureidoadenosine derivatives

[Peterson, Matt A.; Oliveira, Marcelio; Christiansen, Michael A.; Cutler, Christopher E. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 23 p. 6775 - 6779]

Expeditious synthesis of aziridine-based cofactor mimics

[Comstock, Lindsay R; Rajski, Scott R Tetrahedron, 2002 , vol. 58, # 30 p. 6019 - 6026]

Design, synthesis, and molecular modeling studies of 5′-deoxy-5′-ureidoadenosine: 5′-ureido group as multiple hydrogen bonding donor in the active site of S- …

[Wang, Ting; Lee, Hyun Joo; Tosh, Dilip K.; Kim, Hea Ok; Pal, Shantanu; Choi, Sun; Lee, Yoonji; Moon, Hyung Ryong; Zhao, Long Xuan; Lee, Kang Man; Jeong, Lak Shin Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4456 - 4459]

Design, synthesis, and molecular modeling studies of 5′-deoxy-5′-ureidoadenosine: 5′-ureido group as multiple hydrogen bonding donor in the active site of S- …

[Wang, Ting; Lee, Hyun Joo; Tosh, Dilip K.; Kim, Hea Ok; Pal, Shantanu; Choi, Sun; Lee, Yoonji; Moon, Hyung Ryong; Zhao, Long Xuan; Lee, Kang Man; Jeong, Lak Shin Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4456 - 4459]

More Articles...