Adenosine,5'-azido-5'-deoxy-

Modify Date: 2024-02-19 13:06:03

Adenosine,5'-azido-5'-deoxy- Structure
Adenosine,5'-azido-5'-deoxy- structure
 Common Name Adenosine,5'-azido-5'-deoxy-
CAS Number 737-76-8 Molecular Weight 292.25
Density N/A Boiling Point N/A
Molecular Formula C10H12N8O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Adenosine,5'-azido-5'-deoxy-


5′-Azido-5′-deoxyadenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

 Names

Name 2-(6-aminopurin-9-yl)-5-(azidomethyl)oxolane-3,4-diol
Synonym More Synonyms

 Adenosine,5'-azido-5'-deoxy- Biological Activity

Description 5′-Azido-5′-deoxyadenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 Chemical & Physical Properties

Molecular Formula C10H12N8O3
Molecular Weight 292.25
Exact Mass 292.10300
PSA 169.06000

 Synthetic Route

5'-chloro-5'-deoxy-2',3'-O-sulfinyladenosine structure

5'-chloro-5'-de...

CAS#:662131-88-6

~44%

Adenosine,5'-azido-5'-deoxy- Structure

Adenosine,5'-az...

CAS#:737-76-8
Literature: Ciuffreda, Pierangela; Loseto, Angela; Alessandrini, Laura; Terraneo, Giancarlo; Santaniello, Enzo European Journal of Organic Chemistry, 2003 , # 24 p. 4748 - 4751
5'-Chloro-5'-deoxyadenosine structure

5'-Chloro-5'-de...

CAS#:892-48-8

~%

Adenosine,5'-azido-5'-deoxy- Structure

Adenosine,5'-az...

CAS#:737-76-8
Literature: Peterson, Matt A.; Oliveira, Marcelio; Christiansen, Michael A.; Cutler, Christopher E. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 23 p. 6775 - 6779
5-Azido-5-deoxy-2,3-O-isopropylideneadenosine structure

5-Azido-5-deoxy...

CAS#:34245-48-2

~%

Adenosine,5'-azido-5'-deoxy- Structure

Adenosine,5'-az...

CAS#:737-76-8
Literature: Comstock, Lindsay R; Rajski, Scott R Tetrahedron, 2002 , vol. 58, # 30 p. 6019 - 6026
N6-benzoyl-5'-azidoadenosine structure

N6-benzoyl-5'-a...

CAS#:57610-04-5

~%

Adenosine,5'-azido-5'-deoxy- Structure

Adenosine,5'-az...

CAS#:737-76-8
Literature: Wang, Ting; Lee, Hyun Joo; Tosh, Dilip K.; Kim, Hea Ok; Pal, Shantanu; Choi, Sun; Lee, Yoonji; Moon, Hyung Ryong; Zhao, Long Xuan; Lee, Kang Man; Jeong, Lak Shin Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4456 - 4459
5'-azido-5'-deoxy-N6-benzoyl-2',3'-O-isopropylidene adenosine structure

5'-azido-5'-deo...

CAS#:68144-26-3

~%

Adenosine,5'-azido-5'-deoxy- Structure

Adenosine,5'-az...

CAS#:737-76-8
Literature: Wang, Ting; Lee, Hyun Joo; Tosh, Dilip K.; Kim, Hea Ok; Pal, Shantanu; Choi, Sun; Lee, Yoonji; Moon, Hyung Ryong; Zhao, Long Xuan; Lee, Kang Man; Jeong, Lak Shin Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4456 - 4459
N/A structure

N/A

CAS#:40653-96-1

~%

Adenosine,5'-azido-5'-deoxy- Structure

Adenosine,5'-az...

CAS#:737-76-8
Literature: Wang, Ting; Lee, Hyun Joo; Tosh, Dilip K.; Kim, Hea Ok; Pal, Shantanu; Choi, Sun; Lee, Yoonji; Moon, Hyung Ryong; Zhao, Long Xuan; Lee, Kang Man; Jeong, Lak Shin Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4456 - 4459
N6-Benzoyladenosine structure

N6-Benzoyladenosine

CAS#:4546-55-8

~%

Adenosine,5'-azido-5'-deoxy- Structure

Adenosine,5'-az...

CAS#:737-76-8
Literature: Wang, Ting; Lee, Hyun Joo; Tosh, Dilip K.; Kim, Hea Ok; Pal, Shantanu; Choi, Sun; Lee, Yoonji; Moon, Hyung Ryong; Zhao, Long Xuan; Lee, Kang Man; Jeong, Lak Shin Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4456 - 4459
2',3'-O-Isopropylideneadenosine structure

2',3'-O-Isoprop...

CAS#:362-75-4

~%

Adenosine,5'-azido-5'-deoxy- Structure

Adenosine,5'-az...

CAS#:737-76-8
Literature: Comstock, Lindsay R; Rajski, Scott R Tetrahedron, 2002 , vol. 58, # 30 p. 6019 - 6026
Adenosine structure

Adenosine

CAS#:58-61-7

~%

Adenosine,5'-azido-5'-deoxy- Structure

Adenosine,5'-az...

CAS#:737-76-8
Literature: Shelton, Jadd R.; Burt, Scott R.; Peterson, Matt A. Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 5 p. 1484 - 1487

 Synonyms

5'-Azido-5'-desoxy-adenosin
5'-azido-5'-deoxyAdo
5'-Deoxy-5'-azido-adenosin
5'-Deoxy-5'-azidoadenosine
5'-Azidoadenosine
5'-azido-5'-deoxyadenosine
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Related Compounds: More...
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