5-Methoxyindole

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Names

[ CAS No. ]:
1006-94-6

[ Name ]:
5-Methoxyindole

[Synonym ]:
5-Methoxyindole
5-Methoxy indole
5-Methoxy-1H-indole
5-methoxy-indole
Methoxyindole
5-MeO-indole
EINECS 213-745-3
5-methoxy-indol
5-methoxy-2,3-dihydro-1H-indole
1H-Indole, 5-methoxy-
5-Methoxylindole
5-OMe-indole
Femedol
methoxy-5indole
MFCD00005674

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
311.9±0.0 °C at 760 mmHg

[ Melting Point ]:
52-55 °C(lit.)

[ Molecular Formula ]:
C9H9NO

[ Molecular Weight ]:
147.17

[ Flash Point ]:
109.2±10.1 °C

[ Exact Mass ]:
147.068420

[ PSA ]:
25.02000

[ LogP ]:
2.06

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.637

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
insoluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NL9500000
CHEMICAL NAME :
Indole, 5-methoxy-
CAS REGISTRY NUMBER :
1006-94-6
LAST UPDATED :
199109
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C9-H9-N-O
MOLECULAR WEIGHT :
147.19
WISWESSER LINE NOTATION :
T56 BMJ GO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
370 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 9,453,1974

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S24/25-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
NL9500000

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 5-Methoxy-1H-indole-3-carbaldehyde
  • (E)-2-(5-Methoxy-2-nitrophenyl)-N,N-dimethylethenamine
  • 1-pivaloyl-5-methoxyindole
  • 2-ethenyl-4-methoxy-1-nitrobenzene
  • 5-Bromoindole
  • Sodium Methylate
  • (E)-5-methoxy-2-nitro-β-morpholinestyrene
  • TRIETHANOLAMINE HYDROCHLORIDE
  • p-Anisidine
  • N-Boc-5-Methoxyindole

DownStream

  • Roxindole
  • 5-Methoxy-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole
  • 5,5'-dimethoxy-3,3'-(1-methyl-piperidine-4,4-diyl)-bis-indole
  • 1-Boc-3-Bromo-5-methoxyindole
  • 5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE
  • 5-Methoxy-3-indoleaceate
  • 5-Methoxyisatin
  • 5-Methoxyindole-3-acetic acid
  • 1-benzylindol-5-ol
  • 6-Methoxy-2H-3,1-benzoxazine-2,4(1H)-dione

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Prediction of Setschenow constants of N-heteroaromatics in NaCl solutions based on the partial charge on the heterocyclic nitrogen atom.

Environ. Sci. Pollut. Res. Int. 23 , 3399-405, (2016)

The solubilities of 19 different kinds of N-heteroaromatic compounds in aqueous solutions with different concentrations of NaCl were determined at 298.15 K with a UV-vis spectrophotometry and titratio...

Assessment of the pharmacological properties of 5-methoxyindole derivatives at 5-HT4 receptors.

J. Pharm. Pharmacol. 64(8) , 1099-106, (2012)

The aim was to examine the biological activity of 5-methoxytryptamine derivatives at the 5-hydroxytryptamine (5-HT)(4) receptor to explore the effect of substitution on the aliphatic amine of the 5-me...

Rotationally resolved electronic spectroscopy of 5-methoxyindole.

J. Chem. Phys. 133(2) , 024303, (2010)

Rotationally resolved electronic spectra of the vibrationless origin and of eight vibronic bands of 5-methoxyindole (5MOI) have been measured and analyzed using an evolutionary strategy approach. The ...


More Articles

Related Compounds

  • 5-Methoxyindole
  • 5-Methoxyindole,~
  • N-Boc-5-Methoxyindole
  • 5-Methoxyindoleacetate
  • 2-iodo-5-methoxyindole
  • 7-bromo-5-methoxyindole
  • 8,9-dimethoxy-2-[(4-methoxyphenoxy)methyl][1,2,4]triazolo[1,5-c]quinazoline-5(6H)-thione
  • N-(5-((2-((5-methylisoxazol-3-yl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-5-oxo-1-(m-tolyl)pyrrolidine-3-carboxamide
  • (Z)-methyl 2-((5-(3-(benzo[d][1,3]dioxol-5-yl)acrylamido)-1,3,4-thiadiazol-2-yl)thio)acetate
  • N-(benzo[d]thiazol-2-yl)-2-((3-(2-(4-methylphenylsulfonamido)ethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)thio)acetamide
  • 2-(1,2-dimethyl-1H-indol-3-yl)-2-oxo-N-(4-sulfamoylphenethyl)acetamide
  • N-(5-((2-((5-methylisoxazol-3-yl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-5-oxo-1-(o-tolyl)pyrrolidine-3-carboxamide
  • 2-[6-fluoro-3-[(4-methylphenyl)sulfonyl]-4-oxoquinolin-1(4H)-yl]-N-(4-methylphenyl)acetamide
  • 4-chloro-N-(3-(imidazo[1,2-a]pyrimidin-2-yl)phenyl)benzenesulfonamide
  • N-(5-((2-((4-methylthiazol-2-yl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-5-oxo-1-(p-tolyl)pyrrolidine-3-carboxamide
  • N-(4-acetamidophenyl)-2-((6-(benzo[d][1,3]dioxol-5-yl)pyridazin-3-yl)thio)acetamide
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