5-Methoxyindole
5-Methoxyindole structure
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Common Name | 5-Methoxyindole | ||
|---|---|---|---|---|
| CAS Number | 1006-94-6 | Molecular Weight | 147.17 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 311.9±0.0 °C at 760 mmHg | |
| Molecular Formula | C9H9NO | Melting Point | 52-55 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 109.2±10.1 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Prediction of Setschenow constants of N-heteroaromatics in NaCl solutions based on the partial charge on the heterocyclic nitrogen atom.
Environ. Sci. Pollut. Res. Int. 23 , 3399-405, (2016) The solubilities of 19 different kinds of N-heteroaromatic compounds in aqueous solutions with different concentrations of NaCl were determined at 298.15 K with a UV-vis spectrophotometry and titration method, respectively. Setschenow constants, Ks, were empl... |
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Assessment of the pharmacological properties of 5-methoxyindole derivatives at 5-HT4 receptors.
J. Pharm. Pharmacol. 64(8) , 1099-106, (2012) The aim was to examine the biological activity of 5-methoxytryptamine derivatives at the 5-hydroxytryptamine (5-HT)(4) receptor to explore the effect of substitution on the aliphatic amine of the 5-methoxyamine scaffold.Three compounds were tested for affinit... |
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Rotationally resolved electronic spectroscopy of 5-methoxyindole.
J. Chem. Phys. 133(2) , 024303, (2010) Rotationally resolved electronic spectra of the vibrationless origin and of eight vibronic bands of 5-methoxyindole (5MOI) have been measured and analyzed using an evolutionary strategy approach. The experimental results are compared to the results of ab init... |
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Generation of new protein kinase inhibitors utilizing cytochrome p450 mutant enzymes for indigoid synthesis.
J. Med. Chem. 47(12) , 3236-41, (2004) Indigoids, a class of bis-indoles, represent a promising protein kinase inhibitor scaffold. Oxidation of indole by cytochrome P450 (P450) has been shown to generate species (indoxyl, isatin) that couple to yield indigo and indirubin. Escherichia coli-expresse... |
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Optimization of the interligand Overhauser effect for fragment linking: application to inhibitor discovery against Mycobacterium tuberculosis pantothenate synthetase.
J. Am. Chem. Soc. 132(13) , 4544-5, (2010) Fragment-based methods are a new and emerging approach for the discovery of protein binders that are potential new therapeutic agents. Several ways of utilizing structural information to guide the inhibitor assembly have been explored to date. One of the appr... |
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The 5-HT3B subunit confers spontaneous channel opening and altered ligand properties of the 5-HT3 receptor.
J. Biol. Chem. 283(11) , 6826-31, (2008) Current receptor theory suggests that there is an equilibrium between the inactive (R) and active (R*) conformations of ligand-gated ion channels and G protein-coupled receptors. The actions of ligands in both receptor types could be appropriately explained b... |
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Simultaneous liquid chromatographic measurement of melatonin and related indoles through post-column electrochemical demethylation and fluorescence derivatization.
Anal. Sci. 22(2) , 281-6, (2006) In this paper we describe a highly sensitive and selective liquid chromatographic method for the determination of 5-methoxyindoles (5-methoxyindole-3-acetic acid, 5-methoxytryptamine, 5-methoxytryptophol, and melatonin) using a post-column technique involving... |